Evidence map›Paper›PMID 39687981›Full record

Observational studyDiabetic medicine : a journal of the British Diabetic Association2025

Enhanced glucose processing in gestational diabetes diagnosis: Effects on health equity and clinical outcomes.

Danielle L Jones, Laura C Kusinski, Peter Barker, Keith Burling, Ian Halsall, Elizabeth Turner, Coralie Glenn-Sansum, Abby Rand, Jenny Finch, Genessa Peters and 3 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Diabetic medicine : a journal of the British Diabetic Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Danielle L JonesInstitute of Metabolic Science - Medical Research Laboratories, University of Cambridge, Cambridge, UK.
Laura C KusinskiInstitute of Metabolic Science - Medical Research Laboratories, University of Cambridge, Cambridge, UK.
Peter BarkerInstitute of Metabolic Science - Medical Research Laboratories, University of Cambridge, Cambridge, UK.
Keith BurlingInstitute of Metabolic Science - Medical Research Laboratories, University of Cambridge, Cambridge, UK.
Ian HalsallInstitute of Metabolic Science - Medical Research Laboratories, University of Cambridge, Cambridge, UK.
Elizabeth TurnerNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Coralie Glenn-SansumNorth West Anglia NHS Foundation Trust, Peterborough City Hospital, Peterborough, UK.
Abby RandSalisbury NHS Foundation Trust, Salisbury District Hospital, Salisbury, UK.
Jenny FinchEast Suffolk and North Essex Foundation Trust Ipswich Hospital, Ipswich, Colchester, UK.
Genessa PetersEast Suffolk and North Essex Foundation Trust Ipswich Hospital, Ipswich, Colchester, UK.
Geraldine UpsonCroydon Health Services NHS Trust, Croydon University Hospital, Croydon, UK.
Edward MullinsImperial College London and the George Institute for Global Health, London, UK.
Claire L MeekInstitute of Metabolic Science - Medical Research Laboratories, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0002-4176-8329

Funding

Diabetes UKEFSD/Novo Nordisk Foundation Future Leaders Award NNF19SA058974European Foundation for the Study of DiabetesNIHR Cambridge Biomedical Research CentreNIHR Leicester Biomedical Research Centre
6 · The paper itself

Abstract

objectivesGestational diabetes is diagnosed using an oral glucose tolerance test (OGTT), which has limited accuracy, reproducibility and practicality. We assessed the effect of enhanced pre-analytical glucose processing upon glucose concentrations, gestational diabetes diagnosis, health equity and pregnancy outcomes, and if HbA1c was a suitable alternative.

methodsWe recruited pregnant women with ≥1 risk factor to a prospective observational cohort study of pregnancy hyperglycaemia, endocrine causes, lipids, insulin and autoimmunity (OPHELIA), from nine UK centres. During a 75 g antenatal OGTT (National Institute of Health and Care Excellence criteria), standard glucose processing was compared to enhanced glucose processing (storage on ice, rapid centrifugation, aliquoting and freezing <2.5 h).

resultsWe recruited 1308 participants of mean (SD) age 31.5 years (5.0) and BMI 33.0 kg/m

conclusionsAn OGTT with enhanced glucose processing would support more accurate, equitable diagnosis of gestational diabetes, but with increased diagnosis rates.

Indexed as

Blood GlucoseDiabetes, GestationalHealth EquityAdultFemaleGlucose Tolerance TestGlycated HemoglobinHumansPregnancyPregnancy OutcomeProspective StudiesUnited KingdomBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humandiagnosisgestational diabetesglucose analysisHbA1coral glucose tolerance testpre‐analytical factorspregnancy

Identifiers

PMID39687981
PMCPMC11823314

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.