Evidence map›Paper›PMID 39688428›Full record

ArticleMicrobiology spectrum2025

Protease shaving of

Bianca A Lepe, Christine R Zheng, Owen K Leddy, Benjamin L Allsup, Sydney L Solomon, Bryan D Bryson

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Immunodominant Tuberculosis Antigens Recognized by Human CD4Cold Spring Harbor perspectives in medicine · 2026
    Article
  3. Review
  4. Future Research Directions on Mycobacterium tuberculosis Proteins.Advances in experimental medicine and biology · 2026
    Review
  5. The PE/PPE family proteins ofFrontiers in immunology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Bianca A LepeDepartment of Biological Engineering, MIT, Cambridge, Massachusetts, USA.
Christine R ZhengDepartment of Biological Engineering, MIT, Cambridge, Massachusetts, USA.
Owen K LeddyDepartment of Biological Engineering, MIT, Cambridge, Massachusetts, USA.
Benjamin L AllsupDepartment of Biological Engineering, MIT, Cambridge, Massachusetts, USA.
Sydney L SolomonDepartment of Biological Engineering, MIT, Cambridge, Massachusetts, USA.
Bryan D BrysonDepartment of Biological Engineering, MIT, Cambridge, Massachusetts, USA.ORCID 0000-0003-1716-6712

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
TRAINING GRANTS IN ENVIROMENTAL TOXICOLOGYT32ES007020 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2024
$13.1M
Multiplexed Antigen-Specific Antibody Fc Profiling on a Chip for Point-of-Care Diagnosis of TB in HIV-infected ChildrenR01AI152158 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BRYSON, BRYAN DAVID · 2020 to 2024
$4.1M
Dynamics of the cellular and molecular architecture of human pulmonary TB granulomasR01AI166313 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROBERT L MODLIN · 2022 to 2026
$3.2M
High-dimensional characterization of phagosome composition, control and phagocytic receptor redundancyR35GM142900 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI BRYSON, BRYAN DAVID · 2021 to 2025
$2.1M
NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI152158NIAID NIH HHS R01 AI166313NIEHS NIH HHS T32 ES007020NIGMS NIH HHS R35 GM142900
6 · The paper itself

Abstract

Tuberculosis (TB) is the leading cause of infectious disease death and lacks a vaccine capable of protecting adults from pulmonary TB. The bacterial surface is a critical interface that shapes host-pathogen interactions. Several knowledge gaps persist in our understanding of

Indexed as

Antigens, BacterialBacterial ProteinsMycobacterium tuberculosisPeptide HydrolasesTuberculosis VaccinesHost-Pathogen InteractionsHumansMass SpectrometryProteomeProteomicsTuberculosisAntigens, BacterialBacterial ProteinsPeptide HydrolasesProteomeTuberculosis Vaccinescell surfaceproteomicssurface antigenstuberculosis

Identifiers

PMID39688428
PMCPMC11792546

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.