Evidence map›Paper›PMID 39688585›Full record

ReviewEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2024

From bits to bedside: entering the age of digital twins in cardiac electrophysiology.

Pranav Bhagirath, Marina Strocchi, Martin J Bishop, Patrick M Boyle, Gernot Plank

Abstract readReview
In one paragraph

Review in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Imaging phenotypes and substrates in ventricular tachycardia.Herzschrittmachertherapie & Elektrophysiologie · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. A digital twin forJournal of medical microbiology · 2026
    Article
  15. Review
  16. Ablation of atrial fibrillation sources identified through sequential high-density mapping: in silico comparison against anatomy-based approaches.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  17. Automated generation of ablation lesion masks: a unison of electro and optic flow mapping for persistent AF virtual cohorts.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pranav BhagirathDepartment of Cardiology, Amsterdam University Medical Center, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands.ORCID 0000-0003-3732-9304
Marina StrocchiNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0003-1312-251X
Martin J BishopSchool of Biomedical Engineering and Imaging Sciences, King's College London, SE1 7EH London, UK.ORCID 0000-0002-6237-1902
Patrick M BoyleDepartment of Bioengineering, University of Washington, Seattle, USA.ORCID 0000-0001-9048-1239
Gernot PlankGottfried Schatz Research Center, Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.ORCID 0000-0002-7380-6908

Funding

Mechanistic Relationships Between Fibrosis, Fibrillation, and Stroke: Multi-Scale, Multi-Physics SimulationsR01HL158667 · NHLBI · UNIVERSITY OF WASHINGTON · PI Patrick M Boyle · 2022 to 2026
$3.1M
Academy Van Leersum grant of the Academy Medical Sciences FundAmsterdam Cardiovascular SciencesAustrian Science Fund I 6540British Heart Foundation PG/22/10871British Heart Foundation PG/22/11159British Heart Foundation Centre of Research Excellence RE/18/4/34215British Heart Foundation Project Grants PG/18/74/34077Catherine Holmes Wilkins Charitable FoundationCVON PREDICT2 Young Talent ProgramNetherlands Heart InstituteNHLBI NIH HHS R01 HL158667NIH HHS R01-HL158667NIHR Imperial Biomedical Research CentreRoyal Netherlands Academy of Arts and SciencesWellcome EPSRC Centre for Medical Engineering WT 203148/Z/16/ZWellcome TrustWellcome Trust Innovator Award 213342/Z/18/Z
6 · The paper itself

Abstract

This State of the Future Review describes and discusses the potential transformative power of digital twins in cardiac electrophysiology. In this 'big picture' approach, we explore the evolution of mechanistic modelling based digital twins, their current and immediate clinical applications, and envision a future where continuous updates, advanced calibration, and seamless data integration redefine clinical practice of cardiac electrophysiology. Our aim is to inspire researchers and clinicians to embrace the extraordinary possibilities that digital twins offer in the pursuit of precision medicine.

Indexed as

Electrophysiologic Techniques, CardiacArrhythmias, CardiacCardiac ElectrophysiologyHumansModels, CardiovascularPrecision MedicineAtrial fibrillationComputational modellingCRTDigital twinElectrophysiologyPersonalized treatmentVentricular tachycardia

Identifiers

PMID39688585
PMCPMC11649999

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.