Evidence map›Paper›PMID 39689146›Full record

ArticlePloS one2024

Community Health Worker Optimization of Antihypertensive Care in HIV (COACH): Study protocol for a pilot trial of an intervention to improve hypertension care among Tanzanians with HIV.

Wai Yan Min Htike, Preeti Manavalan, Lisa Wanda, Kelvin Haukila, Blandina T Mmbaga, Francis M Sakita, Rennyda Zebedayo, Francis Gwasma, Tazeen Jafar, Hayden B Bosworth and 2 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06503991 (Community and Physician Perceptions of Barriers to Care for Acute Coronary Syndrome Among HIV-infected and -Uninfected Patients in Moshi, Tanzania_1), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06503991 nacompletednot on this map

Community and Physician Perceptions of Barriers to Care for Acute Coronary Syndrome Among HIV-infected and -Uninfected Patients in Moshi, Tanzania_1

TypeinterventionalSponsorDuke UniversityRan2024 to 2025Enrolled100ConditionsHypertension, HIVArmsCommunity Health Worker (CHW)-delivered Hypertension Management Pilot (CHAMP), Control of Blood Pressure and Risk Attenuation (COBRA)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wai Yan Min HtikeDivision of Natural and Applied Science, Duke Kunshan University, Kunshan, Jiangsu, China.ORCID 0009-0001-7284-9826
Preeti ManavalanDepartment of Medicine, University of Florida College of Medicine, Gainesville, FL, United States of America.ORCID 0000-0001-7587-224X
Lisa WandaKilimanjaro Clinical Research Institute, Moshi, Tanzania.
Kelvin HaukilaKilimanjaro Clinical Research Institute, Moshi, Tanzania.
Blandina T MmbagaKilimanjaro Clinical Research Institute, Moshi, Tanzania.
Francis M SakitaKilimanjaro Christian Medical University College, Moshi, Tanzanai.
Rennyda ZebedayoMajengo Health Centre, Moshi, Tanzania.
Francis GwasmaPasua Health Centre, Moshi, Tanzania.
Tazeen JafarProgram in Health Services & Systems Research, Duke-NUS Medical School, Singapore, Singapore.
Hayden B BosworthDuke Clinical Research Institute, Duke University, Durham, NC, United States of America.
Nathan M ThielmanDuke Global Health Institute, Durham, NC, United States of America.
Julian T HertzDuke Global Health Institute, Durham, NC, United States of America.ORCID 0000-0002-7396-4789

Funding

Adapting and Piloting an Evidence-based Intervention to Improve Hypertension Care among Tanzanians Living with HIVR21TW012650 · FIC · DUKE UNIVERSITY · PI HERTZ, JULIAN T, MANAVALAN, PREETI · 2023 to 2024
$392k
FIC NIH HHS R21 TW012650
6 · The paper itself

Abstract

objectiveThis study will evaluate the feasibility and preliminary effectiveness of the COACH (Community Health Worker Optimization of Antihypertensive Care in HIV) intervention, which integrates hypertension management into existing HIV care for people living with HIV (PLWH) in Tanzania.

methodsThe study will be conducted at two HIV Care and Treatment Centers (CTCs) in Tanzania. In a single-arm pre-post feasibility trial, 100 PLWH with hypertension will be enrolled and will receive the six-month intervention. The COACH intervention includes six monthly hypertension educational sessions delivered by community health workers (CHWs) and integrated within HIV CTC visits, monthly blood pressure monitoring, follow up care coordination, fully subsidized antihypertensive medications, a standardized antihypertensive treatment algorithm, and training for providers. The intervention's implementation outcomes will be evaluated using the Reach Effectiveness Adoption Implementation Maintenance (RE-AIM) framework, and the primary study outcome (reach of the intervention) will be the proportion of all scheduled intervention sessions attended by participants, a measure of feasibility. Secondary clinical effectiveness outcomes will include adherence to antihypertensive medication, blood pressure control, body mass index, cardiovascular risk, and hypertension knowledge. SIGNIFICANCE: The COACH intervention has the potential to significantly improve hypertension management among PLWH in Tanzania by leveraging the existing HIV care infrastructure and CHWs. This study will provide crucial insights into the feasibility and potential effectiveness of the intervention in integrating hypertension care into HIV services, informing larger-scale implementation and policy changes in Tanzania and other resource-limitted settings.

trial registrationClinical trials.gov Identifer: NCT06503991.

Indexed as

Antihypertensive AgentsCommunity Health WorkersHIV InfectionsHypertensionAdultEast African PeopleFeasibility StudiesFemaleHumansMaleMiddle AgedPilot ProjectsTanzaniaAntihypertensive Agents

Identifiers

PMID39689146
PMCPMC11651563

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.