Evidence map›Paper›PMID 39690314›Full record

ArticleAnalytical and bioanalytical chemistry2025

Quantification of multi-pathway metabolites related to folate metabolism and application in natural population with MTHFR C677T polymorphism.

Mengdie Wang, Qiwen Zheng, Lei You, Huihui Wang, Peilin Jia, Xinyu Liu, Changqing Zeng, Guowang Xu

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mengdie Wang *State Key Laboratory of Medical Proteomics, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.
Qiwen Zheng *National Genomics Data Center, China National Center for Bioinformation, Beijing, China.
Lei You *State Key Laboratory of Medical Proteomics, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.
Huihui WangInstitute of Biomedical Research, Henan Academy of Sciences, Zhengzhou, China.
Peilin JiaNational Genomics Data Center, China National Center for Bioinformation, Beijing, China.
Xinyu LiuState Key Laboratory of Medical Proteomics, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China. liuxy2012@dicp.ac.cn.
Changqing ZengNational Genomics Data Center, China National Center for Bioinformation, Beijing, China. czeng@big.ac.cn.
Guowang XuState Key Laboratory of Medical Proteomics, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.

Funding

National Key Research and Development Program of China 2022YFC3401200Strategic Priority Research Program (B) of Chinese Academy of Sciences XDB38020200Youth Innovation Promotion Association of the Chinese Academy of Sciences 2021186
6 · The paper itself

Abstract

Folate, serving as a crucial micronutrient, plays an important role in promoting human growth and supporting transformations to a variety of metabolic pathways including one-carbon, pyrimidine, purine, and homocysteine metabolism. The 5,10-methylenetetrahydrofolate reductase (MTHFR) enzyme is pivotal in the folate metabolic pathway. Polymorphism in the MTHFR gene, especially C677T, was associated with decreased enzyme activity and disturbance of folate metabolism, which is linked to various diseases including birth defects in newborns and neural tube abnormalities. However, the detailed metabolic disturbance induced by MTHFR C677T polymorphism is still elusive. In this study, a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the precise quantification of 93 metabolites from six important metabolic pathways related to folate metabolism. The method characteristics demonstrated high accuracy and precision, with r

Indexed as

Folic AcidMethylenetetrahydrofolate Reductase (NADPH2)Chromatography, LiquidFemaleHumansMaleMetabolic Networks and PathwaysPolymorphism, GeneticPolymorphism, Single NucleotideTandem Mass SpectrometryTetrahydrofolates5-methyltetrahydrofolateFolic AcidMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanTetrahydrofolatesFolateLiquid chromatography-tandem mass spectrometryMTHFR C677T polymorphismOne-carbon metabolism

Identifiers

PMID39690314

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.