Evidence map›Paper›PMID 39690366›Full record

ArticleJournal of molecular neuroscience : MN2024

Lack of Association between BDNF rs6265 and Multiple Sclerosis: A Case-Control Study.

Ioannis Liampas, Daniil Tsirelis, Metaxia Dastamani, Stavroula-Ioanna Pariou, Maria Papasavva, Martha-Spyridoula Katsarou, Annia Tsolakou, Aristidis Tsatsakis, Dimitrios P Bogdanos, Nikolaos Drakoulis and 2 more

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Article in Journal of molecular neuroscience : MN, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ioannis LiampasDepartment of Neurology, School of Medicine, University Hospital of Larissa, University of Thessaly, 41110, Larissa, Greece.
Daniil TsirelisDepartment of Neurology, School of Medicine, University Hospital of Larissa, University of Thessaly, 41110, Larissa, Greece.
Metaxia DastamaniDepartment of Neurology, School of Medicine, University Hospital of Larissa, University of Thessaly, 41110, Larissa, Greece.
Stavroula-Ioanna PariouResearch Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece.
Maria PapasavvaResearch Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece.
Martha-Spyridoula KatsarouResearch Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece.
Annia TsolakouResearch Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece.
Aristidis TsatsakisLaboratory of Toxicology, School of Medicine, University of Crete, 71003, Heraklion, Greece.
Dimitrios P BogdanosDepartment of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University General Hospital of Larissa, University of Thessaly, Viopolis 40500, Larissa, Greece.
Nikolaos DrakoulisResearch Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece.
Efthimios Dardiotis *Department of Neurology, School of Medicine, University Hospital of Larissa, University of Thessaly, 41110, Larissa, Greece.
Vasileios Siokas *Department of Neurology, School of Medicine, University Hospital of Larissa, University of Thessaly, 41110, Larissa, Greece. vsiokas@med.uth.gr.

Funding

Research Committee of the University of Thessaly, Greece 5287
6 · The paper itself

Abstract

BACKGROUND AND

objectivesData on the association between BDNF rs6265 and multiple sclerosis (MS) are scarce and heterogeneous. MATERIALS AND

methodsWe undertook a case-control study design. Newly diagnosed individuals with MS based on the 2017 revision of the McDonald criteria were recruited from the Neurology Department of the General University Hospital of Larissa. Healthy controls with a free medical and family history were also recruited. The relationship between BDNF rs6265 and MS was defined as the primary outcome. The association between rs6265 and age of MS onset, spinal lesions, and clinical manifestations at the time of MS onset were defined as the secondary outcomes.

resultsWe genotyped a total of 200 patients with MS and 205 healthy controls, yielding a sample power of approximately 80%. BDNF rs6265 was in Hardy-Weinberg Equilibrium among healthy participants (p = 0.64). No significant relationship was revealed between rs6265 and MS [log-additive OR = 0.83 (0.57,1.21), over-dominant OR = 0.73 (0.48,1.14), recessive OR = 1.24 (0.37,4.12), dominant OR = 0.77 (0.50,1.17), co-dominant OR1 = 0.74 (0.48,1.14) and co-dominant OR2 = 1.13 (0.34,3.80)]. Additionally, rs6265 was unrelated to the age of MS onset according to both unadjusted and sex-adjusted cox-proportional models. Finally, rs6265 was not associated with the presence of spinal lesions (cervical or thoracic) at MS onset, according to both unadjusted and age and sex-adjusted logistic regression models.

conclusionsWe failed to establish an association between BDNF rs6265 and the risk of MS, the age of onset, the presence of spinal lesions, and the clinical manifestations at the onset.

Indexed as

Brain-Derived Neurotrophic FactorMultiple SclerosisPolymorphism, Single NucleotideAdultAge of OnsetCase-Control StudiesFemaleHumansMaleMiddle AgedBDNF protein, humanBrain-Derived Neurotrophic FactorBDNFMultiple sclerosisrs6265

Identifiers

PMID39690366

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.