Evidence map›Paper›PMID 39690809›Full record

ArticleAdvanced healthcare materials2025

PSMA-Targeting Imprinted Nanogels for Prostate Tumor Localization and Imaging.

Tong Zhang, Melanie Berghaus, Yuan Li, Qingmei Song, Maria M Stollenwerk, Jenny Persson, Kenneth J Shea, Börje Sellergren, Yongqin Lv

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  3. Article
  4. Review
  5. Review
  6. [Molecular imprinting strategies and advances targeting biomembranes].Se pu = Chinese journal of chromatography · 2026
    Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tong ZhangState Key Laboratory of Organic-Inorganic Composites, International Joint Bioenergy Laboratory of Ministry of Education, National Energy Research and Development Center for Biorefinery, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.
Melanie BerghausDepartment of Chemistry and Chemical Biology, TU Dortmund University, 44227, Dortmund, Germany.
Yuan LiState Key Laboratory of Organic-Inorganic Composites, International Joint Bioenergy Laboratory of Ministry of Education, National Energy Research and Development Center for Biorefinery, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.
Qingmei SongState Key Laboratory of Organic-Inorganic Composites, International Joint Bioenergy Laboratory of Ministry of Education, National Energy Research and Development Center for Biorefinery, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.
Maria M StollenwerkDepartment of Biomedical Sciences, Faculty of Health and Society, Malmö University, Malmö, 20506, Sweden.
Jenny PerssonDepartment of Biomedical Sciences, Faculty of Health and Society, Malmö University, Malmö, 20506, Sweden.
Kenneth J SheaDepartment of Chemistry, University of California Irvine, California, 92697, USA.
Börje SellergrenDepartment of Biomedical Sciences, Faculty of Health and Society, Malmö University, Malmö, 20506, Sweden.
Yongqin LvState Key Laboratory of Organic-Inorganic Composites, International Joint Bioenergy Laboratory of Ministry of Education, National Energy Research and Development Center for Biorefinery, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.ORCID 0000-0001-9030-8006

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Fundamental Research Funds for the Central Universities QNTD2023-01National Natural Science Foundation of China 22122801NCI NIH HHS P30 CA062203
6 · The paper itself

Abstract

Prostate-specific membrane antigen (PSMA) is overexpressed in prostate cancer cells and tumor vasculature, making it an important biomarker. However, conventional PSMA-targeting agents like antibodies and small molecules have limitations. Antibodies exhibit instability and complex production, while small molecules show lower specificity and higher toxicity. Herein, this work develops a novel PSMA-targeting synthetic antibody to address prior limitations. This work synthesizes fluorescently labelled, N-isopropylacrylamide-based epitope imprinted nanogels (MIP-M) using a dispersion of magnetic nanoparticles as template carriers with a linear epitope from PSMA's extracellular apical domain as the template. MIP-M demonstrates high binding affinities for both the epitope template (apparent K

Indexed as

Antigens, SurfaceGlutamate Carboxypeptidase IINanogelsProstatic NeoplasmsAcrylamidesCell Line, TumorEpitopesHumansMaleMolecular ImprintingAcrylamidesAntigens, SurfaceEpitopesFOLH1 protein, humanGlutamate Carboxypeptidase IINanogelsdispersed‐phase imprintingmolecularly imprinted nanogelsprostate cancerprostate‐specific membrane antigentissue imaging

Identifiers

PMID39690809
PMCPMC12753134

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.