Evidence map›Paper›PMID 39692936›Full record

ArticleBotanical studies2024

Antioxidant, anti-acetylcholinesterase, and anti-amyloid-β peptide aggregations of hispolon and its analogs in vitro and improved learning and memory functions in scopolamine-induced ICR mice.

Chang-Hang Yang, Cai-Wei Li, Yi-Yan Sie, Liang-Chieh Chen, Yu-Hsiang Yuan, Wen-Chi Hou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Botanical studies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chang-Hang Yang *Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, 110, Taiwan.
Cai-Wei LiGraduate Institute of Pharmacognosy, Taipei Medical University, Taipei, 110, Taiwan.
Yi-Yan SieClinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei, 110, Taiwan.
Liang-Chieh Chen *School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, 804, Taiwan.
Yu-Hsiang YuanGraduate Institute of Pharmacognosy, Taipei Medical University, Taipei, 110, Taiwan.
Wen-Chi HouGraduate Institute of Pharmacognosy, Taipei Medical University, Taipei, 110, Taiwan. wchou@tmu.edu.tw.ORCID http://orcid.org/0000-0002-9565-7018

Funding

Ministry of Science and Technology, Taiwan MOST 107-2320-B-038 -027
6 · The paper itself

Abstract

backgroundHispolon, one of bioactive phenolic compounds from a medicinal mushroom of sang-huang (Phellinus linteus) has been reported to exhibit anticancer and anti-inflammatory activities. The Alzheimer's disease (AD) is ranked one of the top ten leading causes of death worldwide. Little is known about the effects of hispolon on delaying AD progression.

resultsThe hispolon (No.1) and its six structural analogs (No.2 to No.7) were assayed by antioxidant, anti-acetylcholinesterase activities and anti-amyloid-β

conclusionThe hispolon in the fungus sang-huang might be beneficial to develop functional foods or as lead compounds for treating degenerative disorders.

Indexed as

Acetylcholinesteraseamyloid-β1−42-peptide aggregationsHispolonScopolamine

Identifiers

PMID39692936
PMCPMC11655744

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.