Evidence mapPaperPMID 39694536Full record

ArticleAmerican journal of physiology. Renal physiology2025

Intestinal barrier function declines during polycystic kidney disease progression.

Randee Sedaka, Caleb Lovelady, Emily Hallit, Branden Duyvestyn, Sejal Shinde, Aida Moran-Reyna, Goo Lee, Shinobu Yamaguchi, Craig L Maynard, Takamitsu Saigusa

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Randee SedakaSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Alabama, United States.
Caleb LoveladySection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Alabama, United States.
Emily HallitSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Alabama, United States.
Branden DuyvestynSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Alabama, United States.
Sejal ShindeSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Alabama, United States.
Aida Moran-ReynaSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Alabama, United States.
Goo LeeDivision of Anatomic Pathology, Department of Pathology, University of Alabama at Birmingham, Alabama, United States.ORCID 0000-0003-3025-5234
Shinobu YamaguchiSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Alabama, United States.
Craig L MaynardDivision of Molecular & Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Alabama, United States.ORCID 0000-0001-5876-8168
Takamitsu SaigusaSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Alabama, United States.ORCID 0000-0002-2398-1572

Funding

TRAINING IN CELLULAR PHYSIOLOGY MEMBRANE TRANSPORTT32DK007545 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 1987 to 2005
$660k
The Role of Wheat-Gluten in Polycystic Kidney DiseaseR01DK132028 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$297k
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK132028HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK007545NIDDK NIH HHS R01 DK132028NIDDK NIH HHS T32 DK007545
6 · The paper itself

Abstract

Most patients with autosomal dominant polycystic kidney disease (ADPKD) develop kidney cysts due to germline

Indexed as

Intestinal MucosaKidneyPolycystic Kidney, Autosomal DominantTRPP Cation ChannelsAnimalsDisease Models, AnimalDisease ProgressionIntestinal Barrier FunctionMaleMiceMice, KnockoutPermeabilityTRPP Cation ChannelsADPKDcolonintegritymotilitywater

Identifiers

PMID39694536
PMCPMC12176450

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.