Evidence map›Paper›PMID 39694612›Full record

ArticleAJNR. American journal of neuroradiology2025

Correlation between P2-PCA Volume Flow Rate and BOLD Cerebrovascular Reactivity in Patients with Symptomatic Carotid Artery Occlusion.

Amely Walser, Jorn Fierstra, Lara Maria Höbner, Jacopo Bellomo, Tilman Schubert, Menno Germans, Vittorio Stumpo, Christiaan Hendrik Bas van Niftrik, Susanne Wegener, Andreas R Luft and 4 more

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Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Amely WalserFrom the Department of Neurosurgery (G.E., M.S., A.W., J.F., L.M.H., J.B., M.G., V.S., C.H.B.v.N., L.R.), University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Jorn FierstraFrom the Department of Neurosurgery (G.E., M.S., A.W., J.F., L.M.H., J.B., M.G., V.S., C.H.B.v.N., L.R.), University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0001-6220-0727
Lara Maria HöbnerFrom the Department of Neurosurgery (G.E., M.S., A.W., J.F., L.M.H., J.B., M.G., V.S., C.H.B.v.N., L.R.), University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Jacopo BellomoFrom the Department of Neurosurgery (G.E., M.S., A.W., J.F., L.M.H., J.B., M.G., V.S., C.H.B.v.N., L.R.), University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0009-0005-8945-4838
Tilman SchubertClinical Neuroscience Center (M.S., A.W., J.F., L.M.H., J.B., M.G., V.S., C.H.B.v.N., L.R., T.S., S.W., A.R.L., Z.K.), University Hospital Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0003-2373-5870
Menno GermansFrom the Department of Neurosurgery (G.E., M.S., A.W., J.F., L.M.H., J.B., M.G., V.S., C.H.B.v.N., L.R.), University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Vittorio StumpoFrom the Department of Neurosurgery (G.E., M.S., A.W., J.F., L.M.H., J.B., M.G., V.S., C.H.B.v.N., L.R.), University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-8175-0035
Christiaan Hendrik Bas van NiftrikFrom the Department of Neurosurgery (G.E., M.S., A.W., J.F., L.M.H., J.B., M.G., V.S., C.H.B.v.N., L.R.), University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0003-0930-8717
Susanne WegenerClinical Neuroscience Center (M.S., A.W., J.F., L.M.H., J.B., M.G., V.S., C.H.B.v.N., L.R., T.S., S.W., A.R.L., Z.K.), University Hospital Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0003-4369-7023
Andreas R LuftClinical Neuroscience Center (M.S., A.W., J.F., L.M.H., J.B., M.G., V.S., C.H.B.v.N., L.R., T.S., S.W., A.R.L., Z.K.), University Hospital Zurich, Zurich, Switzerland.
Zsolt KulcsárClinical Neuroscience Center (M.S., A.W., J.F., L.M.H., J.B., M.G., V.S., C.H.B.v.N., L.R., T.S., S.W., A.R.L., Z.K.), University Hospital Zurich, Zurich, Switzerland.
Luca RegliFrom the Department of Neurosurgery (G.E., M.S., A.W., J.F., L.M.H., J.B., M.G., V.S., C.H.B.v.N., L.R.), University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0003-4639-4474
Giuseppe EspositoFrom the Department of Neurosurgery (G.E., M.S., A.W., J.F., L.M.H., J.B., M.G., V.S., C.H.B.v.N., L.R.), University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Martina SebökFrom the Department of Neurosurgery (G.E., M.S., A.W., J.F., L.M.H., J.B., M.G., V.S., C.H.B.v.N., L.R.), University Hospital Zurich, University of Zurich, Zurich, Switzerland martina.seboek@usz.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeIdentifying and assessing hemodynamic and flow status in patients with symptomatic ICA occlusion is crucial for evaluating recurrent stroke risk. The aim of this study was to analyze the correlation between 2 quantitative imaging modalities: 1) blood oxygenation level-dependent (BOLD) cerebrovascular reactivity (CVR) and 2) quantitative MR angiography (qMRA) with noninvasive optimal vessel analysis (NOVA), measuring volume flow rate (VFR). Comparing these modalities is relevant for assessing collateral circulation and hemodynamic impairment. MATERIALS AND

methodsIn this retrospective analysis of prospectively collected data, 37 symptomatic patients with unilateral ICA occlusion, who underwent both NOVA-qMRA and BOLD-CVR investigation, were included. The correlation analysis between NOVA-qMRA-derived second segment of the posterior cerebral artery (PCA-P2) VFR and BOLD-CVR (hemispheric and MCA territory CVR) was done by using a linear mixed-effects model.

resultsA moderate correlation was found between P2-VFR and BOLD-CVR values for the ipsilateral MCA territory (

conclusionsThis correlation suggests that impaired BOLD-CVR is partly linked to an increased PCA-P2 volume flow rate, potentially indicating the activation of leptomeningeal collaterals in severe hemodynamic conditions. Both imaging techniques could aid clinicians in creating personalized treatment strategies for patients with symptomatic ICA occlusion.

Indexed as

Carotid StenosisCerebrovascular CirculationMagnetic Resonance AngiographyPosterior Cerebral ArteryAgedBlood Flow VelocityCollateral CirculationFemaleHumansMaleMiddle AgedRetrospective Studies

Identifiers

PMID39694612
PMCPMC12453438

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.