Evidence map›Paper›PMID 39695169›Full record

ArticleScientific data2024

Petagraph: A large-scale unifying knowledge graph framework for integrating biomolecular and biomedical data.

Benjamin J Stear, Taha Mohseni Ahooyi, J Alan Simmons, Charles Kollar, Lance Hartman, Katherine Beigel, Aditya Lahiri, Shubha Vasisht, Tiffany J Callahan, Christopher M Nemarich and 2 more

Abstract read
In one paragraph

Article in Scientific data, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. The Common Fund Data Ecosystem (CFDE).bioRxiv : the preprint server for biology · 2026
    Article
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  5. Article
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  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Benjamin J Stear *Department of Biomedical and Health Informatics (DBHI), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-2972-0354
Taha Mohseni Ahooyi *Department of Biomedical and Health Informatics (DBHI), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
J Alan SimmonsDepartment of Biomedical Informatics, School of Medicine, The University of Pittsburgh, Pittsburgh, PA, USA.
Charles KollarDepartment of Biomedical Informatics, School of Medicine, The University of Pittsburgh, Pittsburgh, PA, USA.
Lance HartmanDepartment of Biomedical and Health Informatics (DBHI), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Katherine BeigelDepartment of Biomedical and Health Informatics (DBHI), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Aditya LahiriDepartment of Biomedical and Health Informatics (DBHI), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Shubha VasishtDepartment of Biomedical and Health Informatics (DBHI), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Tiffany J CallahanDepartment of Biomedical Informatics, Columbia University Irving Medical Campus, New York, NY, USA.ORCID 0000-0002-8169-9049
Christopher M NemarichDepartment of Biomedical and Health Informatics (DBHI), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jonathan C SilversteinDepartment of Biomedical Informatics, School of Medicine, The University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-9252-6039
Deanne M TaylorDepartment of Biomedical and Health Informatics (DBHI), The Children's Hospital of Philadelphia, Philadelphia, PA, USA. taylordm@chop.edu.ORCID 0000-0002-3302-4610

Funding

Utilizing FHIR to expand the availability of interoperable clinical and phenotypic data to the pediatric research communityU2CHD109731 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Adam Cain Resnick · 2022 to 2026
$31.6M
SenNet Supplement - Consortium BenchmarkingU24CA268108 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Philip D. Blood, JONATHAN C. SILVERSTEIN · 2021 to 2026
$22.1M
U2C Kids First Admin Supplement - data transferU2CHL138346 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI HEATH, ALLISON · 2017 to 2022
$21.5M
Flexible Hybrid Cloud Infrastructure for Seamless Integration and Use of Human Biomolecular Data and Reference Maps [1 of 5]OT2OD033759 · OD · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D., SILVERSTEIN, JONATHAN C. · 2022 to 2025
$20.4M
Kids First Data Resource Center (KFDRC): Harnessing Data-Driven Opportunities in the Present on behalf of the Future of Common Fund Data Ecosystem (CFDE)OT2OD030162 · OD · CHILDREN'S HOSP OF PHILADELPHIA · PI DIGIOVANNA, JACK, HEATH, ALLISON · 2020 to 2025
$10.7M
Flexible Hybrid Cloud Infrastructure for Seamless Management of HuBMAP Resources, Including Consortium-Wide and External EngagementOT2OD026675 · OD · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D., SILVERSTEIN, JONATHAN C. · 2018 to 2021
$8.9M
Amplifying the Value of HuBMAP Data Through Data Interoperability and CollaborationOT2OD030545 · OD · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D., BORNER, KATY · 2020 to 2023
$3.1M
HuBMAP Integration, Visualization and Engagement by Modular Integration of Novel Databases (HIVE-MIND) Collaboration Component (CC)OT2OD026663 · OD · UNIVERSITY OF SOUTH DAKOTA · PI LENHARDT, WILLIAM CHRISTOPHER, MABEE, PAULA M · 2018 to 2019
$585k
Leveraging Common Fund data for feature selection in Kids First studies.R03OD030600 · OD · CHILDREN'S HOSP OF PHILADELPHIA · PI TAYLOR, DEANNE MARIE · 2020 to 2020
$363k
NCI NIH HHS U24 CA268108NHLBI NIH HHS U2C HL138346NICHD NIH HHS U2C HD109731NIH HHS OT2 OD026663NIH HHS OT2 OD026675NIH HHS OT2 OD030162NIH HHS OT2 OD030545NIH HHS OT2 OD033759NIH HHS R03 OD030600U.S. Department of Health & Human Services | NIH | Office of Strategic Coordination (OSC) 9U2CHD109731U.S. Department of Health & Human Services | NIH | Office of Strategic Coordination (OSC) OT2OD026663U.S. Department of Health & Human Services | NIH | Office of Strategic Coordination (OSC) OT2OD026675U.S. Department of Health & Human Services | NIH | Office of Strategic Coordination (OSC) OT2OD030162U.S. Department of Health & Human Services | NIH | Office of Strategic Coordination (OSC) R03OD030600
6 · The paper itself

Abstract

Over the past decade, there has been substantial growth in both the quantity and complexity of available biomedical data. In order to more efficiently harness this extensive data and alleviate challenges associated with integration of multi-omics data, we developed Petagraph, a biomedical knowledge graph that encompasses over 32 million nodes and 118 million relationships. Petagraph leverages more than 180 ontologies and standards in the Unified Biomedical Knowledge Graph (UBKG) to embed millions of quantitative genomics data points. Petagraph provides a cohesive data environment that enables users to efficiently analyze, annotate, and discern relationships within and across complex multi-omics datasets supported by UBKG's annotation scaffold. We demonstrate how queries on Petagraph can generate meaningful results across various research contexts and use cases.

Indexed as

GenomicsBiological Ontologies

Identifiers

PMID39695169
PMCPMC11655564

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.