ArticleNature2025
Lithocholic acid phenocopies anti-ageing effects of calorie restriction.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping arterial stiffness metabolic biomarkers: a bibliometric analysis.Frontiers in medicine · 2025Pooled it
- Effect of henagliflozin on aging biomarkers in patients with type 2 diabetes: A multicenter, randomized, double-blind, placebo-controlled study.Cell reports. Medicine · 2025Trial
- The gut microbiome-bile acid-FXR interplay: a pivotal axis in metabolic and gastrointestinal diseases.Gut microbes · 2026Review
- Lithocholic acid alleviates fatty liver in mice and non-human primate macaques.Life metabolism · 2026Article
- Microbiota-gut-brain axis and bile acids-driven neuromodulation.Neural regeneration research · 2026Article
- Article
- AMPK Therapy-A Little Goes A Long Way.Cells · 2026Review
- Amide-functionalized cholic acid hybrids: design, bioactivity, and computational analysis.RSC advances · 2026Article
- Gaps in the Parkinson's disease therapeutic clinical pipeline: A focus on approaches targeting disease pathobiology.Journal of Parkinson's disease · 2026Review
- Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers.MedComm · 2026Review
- Intracellular lipid droplets positively regulate the dormancy of colorectal cancer cells depending on ELF1-ACSL5 signaling.Journal of experimental & clinical cancer research : CR · 2026Article
- Dimethyl fumarate ameliorates quinolinic acid-induced ageing and neurodegeneration in Caenorhabditis elegans.Biogerontology · 2026Article
- Untargeted metabolomics reveals effects of calorie restriction on skeletal muscle in older female and male rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Insights into the therapeutic strategies for aging and aging-associated diseases.Signal transduction and targeted therapy · 2026Review
- Metformin beyond Glycemic Control: New Mechanistic Insights and Expanding Therapeutic Horizons.Diabetes & metabolism journal · 2026Review
- Pharmacologic AMPK Activation Extends Lifespan inbioRxiv : the preprint server for biology · 2026Article
- White adipose atrophy exacerbates cold stress and accelerates aging in male mice.Nature communications · 2026Article
- Probiotic Bifidobacterium animalis subsp. lactis DS109-B11 ameliorates age-related muscle weakness via AMPK activation.Scientific reports · 2026Article
- TRPC6 governs brown adipose thermogenesis via a BMPR2-p38 MAPK signaling axis.Molecular metabolism · 2026Article
- Gut microbiota-derived metabolites as immune modulators in aging and age-related chronic inflammatory diseases.Ageing research reviews · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
27 authors.
Qi Qu *State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Yan Chen *State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Yu Wang *State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.ORCID 0009-0000-5023-5260
Shating LongState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Weiche WangState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Heng-Ye YangState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Mengqi LiState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.ORCID 0000-0002-1171-5648
Xiao TianState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Xiaoyan WeiState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Yan-Hui LiuState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Shengrong XuState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Cixiong ZhangState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Mingxia ZhuState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.ORCID 0000-0002-1858-5655
Sin Man LamLipidALL Technologies, Changzhou, China.ORCID 0000-0001-9037-904X
Jianfeng WuLaboratory Animal Research Centre, Xiamen University, Fujian, China.
Chuyu YunState Key Laboratory of Female Fertility Promotion, Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital, Beijing, China.
Junjie ChenAnalysis and Measurement Centre, School of Pharmaceutical Sciences, Xiamen University, Fujian, China.
Shengye XueState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Baoding ZhangState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Zhong-Zheng ZhengState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Hai-Long PiaoCAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Liaoning, China.ORCID 0000-0001-7451-0386
Changtao JiangDepartment of Physiology and Pathophysiology, Department of Immunology, School of Basic Medical Sciences, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodelling, Peking University, Beijing, China.ORCID 0000-0002-5206-2372
Hao GuoState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Guanghou ShuiInstitute of Genetics and Development Biology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-1621-9643
Xianming DengState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.ORCID 0000-0002-9354-5864
Chen-Song ZhangState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China. cszhang@xmu.edu.cn.ORCID 0000-0001-5218-0101
Sheng-Cai LinState Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China. linsc@xmu.edu.cn.ORCID 0000-0003-1993-8376
Funding
Innovation of Science and Technology, Fujian provinceResearch Center of Metabolism, the XMU Open Innovation Fund and Training Programme of Innovation and Entrepreneurship for Undergraduates
Abstract
Calorie restriction (CR) is a dietary intervention used to promote health and longevity
Indexed as
AgingCaloric RestrictionLithocholic AcidAMP-Activated Protein KinasesAnimalsCaenorhabditis elegansDrosophila melanogasterEnzyme ActivationFemaleHand StrengthLongevityMaleMetabolomicsMicePhenotypeRegenerationAMP-Activated Protein KinasesLithocholic Acid
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.