Evidence map›Paper›PMID 39695421›Full record

ArticleBMC genomics2024

Profiling of blood miRNAomes revealed the potential regulatory role of miRNAs in various lameness phenotypes in feedlot cattle.

Zhe Pan, Wentao Li, Sonja Bialobzyski, Yanhong Chen, Eoin O'Hara, Hui-Zeng Sun, Karen Schwartzkopf-Genswein, Le Luo Guan

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In one paragraph

Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhe Pan *Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G2P5, Canada.
Wentao Li *Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G2P5, Canada.
Sonja BialobzyskiFaculty of Land and Food Systems, The University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
Yanhong ChenDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G2P5, Canada.
Eoin O'HaraAgriculture and Agri-Food Canada, Lethbridge, AB, T1J 4B1, Canada.
Hui-Zeng SunInstitute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
Karen Schwartzkopf-GensweinAgriculture and Agri-Food Canada, Lethbridge, AB, T1J 4B1, Canada.
Le Luo GuanDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G2P5, Canada. leluo.guan@ubc.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLameness is a collective term for multiple foot diseases in cattle including, but not limited to, foot rot (FR), digital dermatitis (DD), and toe tip necrosis (TTN), which is a critical welfare concern. The diagnosis of specific phenotypes of lameness in feedlot cattle is challenging and primarily relies on visual assessments. However, different lameness phenotypes share similar clinical symptoms and there is a limited understanding of potential biomarkers relating to such disease for further molecular diagnosis. This study aimed to identify blood miRNA profiles of feedlot cattle with various lameness phenotypes and whether they could be potential diagnostic markers to differentiate lameness phenotypes and predictive lameness recovery.

resultsMicroRNAome profiles were generated for the whole blood samples collected from feedlot cattle at Week 0 (W0) before treatment (n = 106) and longitudinal miRNA expression profiles relating to lameness recovery from W0 to W2 (n = 140) using RNA-seq. Ten miRNAs were selected to verify miRNA sequencing accuracy using stem-loop RT-qPCR. A total of 321 miRNAs were identified to be expressed in bovine blood samples with three (all downregulated, average log

conclusionOur results comprehensively assessed the blood miRNAomes in response to various lameness phenotypes, promoting the understanding of miRNA-regulated mechanisms of lameness in feedlot cattle. The diagnostic miRNA markers were also identified to differentiate within lameness phenotypes and predictive lameness recovery, shedding light on accurate on-farm lameness detection.

Indexed as

Cattle DiseasesLameness, AnimalMicroRNAsPhenotypeAnimalsBiomarkersCattleGene Expression ProfilingGene Expression RegulationBiomarkersMicroRNAsBlood miRNAsDiagnostic markersDigital dermatitisFoot rotLamenessMiRNAomesToe tip necrosis

Identifiers

PMID39695421
PMCPMC11653651

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.