Evidence map›Paper›PMID 39695919›Full record

ArticleThe journal of headache and pain2024

Ca

Darciane F Baggio, Eder Gambeta, Ivana A Souza, Sun Huang, Gerald W Zamponi, Juliana G Chichorro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Darciane F BaggioDepartment of Pharmacology, Biological Sciences Sector, Federal University of Parana, Curitiba, PR, Brazil.
Eder GambetaDepartment of Clinical Neuroscience, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Ivana A SouzaDepartment of Clinical Neuroscience, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Sun HuangDepartment of Clinical Neuroscience, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Gerald W ZamponiDepartment of Clinical Neuroscience, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Juliana G ChichorroDepartment of Pharmacology, Biological Sciences Sector, Federal University of Parana, Curitiba, PR, Brazil. juliana.chichorro@ufpr.br.

Funding

CAPES PhD scholarship 001CNPq Research Productivity scholarship 303781/2020-3
6 · The paper itself

Abstract

backgroundMigraine is a painful neurological syndrome characterized by attacks of throbbing headache, of moderate to severe intensity, which is associated with photo- and phono- sensitivity as well as nausea and vomiting. It affects about 15% of the world's population being 2-3 times more prevalent in females. The calcitonin gene-related peptide (CGRP) is a key mediator in the pathophysiology of migraine, and a significant advance in the field has been the development of anti-CGRP therapies. The trigeminal ganglion (TG) is thought to be an important site of action for these drugs. Moreover, experimental migraine can be induced by CGRP injection in the TG. The signaling pathway induced by CGRP in the TG is not fully understood, but studies suggest that voltage-gated calcium channels contribute to CGRP effects relevant to migraine.

objectiveWe hypothesised that CGRP injection in the TG enhances Ca

resultsA Co-Immunoprecipitation assay in tsA-201 cells revealed that Ca

conclusionThe present study suggests that CGRP modulates Ca

Indexed as

Calcitonin Gene-Related PeptideCalcium Channels, T-TypeDisease Models, AnimalHyperalgesiaMigraine DisordersReceptor Activity-Modifying Protein 1Trigeminal GanglionAnimalsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutRatsCacna1h protein, mouseCalcitonin Gene-Related PeptideCalcium Channels, T-TypeReceptor Activity-Modifying Protein 1Calcitonin gene-related peptideElectrophysiologyMicePeriorbital mechanical allodyniaRAMP-1Trigeminal ganglionVoltage-gated calcium channels

Identifiers

PMID39695919
PMCPMC11656763

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.