Evidence map›Paper›PMID 39696018›Full record

Trial reportBMC psychiatry2024

Emotional processing as mechanism of change in brief good psychiatric management for borderline personality disorder: results of a randomized controlled trial.

Ueli Kramer, Loris Grandjean, José Blanco Machinea, Hélène Beuchat, Setareh Ranjbar, Yves de Roten, Jean-Nicolas Despland, Philippe Conus, Stéphane Kolly

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03717818 (Mechanisms of Change in Brief Treatment for Borderline Personality Disorder), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03717818 naunknown statusnot on this map

Mechanisms of Change in Brief Treatment for Borderline Personality Disorder: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of Lausanne HospitalsRan2018 to 2022Enrolled80ConditionsBorderline Personality DisorderArmsGood Psychiatric Management - Brief, treatment as usual
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ueli KramerUniversity Institute of Psychotherapy, Department of Psychiatry, University of Lausanne and Lausanne University Hospital, Route de Cery 1, CH-1008, Prilly-Lausanne, Switzerland. Ueli.Kramer@chuv.ch.
Loris GrandjeanUniversity Institute of Psychotherapy, Department of Psychiatry, University of Lausanne and Lausanne University Hospital, Route de Cery 1, CH-1008, Prilly-Lausanne, Switzerland.
José Blanco MachineaUniversity Institute of Psychotherapy, Department of Psychiatry, University of Lausanne and Lausanne University Hospital, Route de Cery 1, CH-1008, Prilly-Lausanne, Switzerland.
Hélène BeuchatGeneral Psychiatry Service, Department of Psychiatry, Lausanne University Clinic and University of Lausanne, Lausanne, Switzerland.
Setareh RanjbarDepartment of Psychiatry, Lausanne University Clinic and University of Lausanne, Lausanne, Switzerland.
Yves de RotenUniversity Institute of Psychotherapy, Department of Psychiatry, University of Lausanne and Lausanne University Hospital, Route de Cery 1, CH-1008, Prilly-Lausanne, Switzerland.
Jean-Nicolas DesplandUniversity Institute of Psychotherapy, Department of Psychiatry, University of Lausanne and Lausanne University Hospital, Route de Cery 1, CH-1008, Prilly-Lausanne, Switzerland.
Philippe ConusGeneral Psychiatry Service, Department of Psychiatry, Lausanne University Clinic and University of Lausanne, Lausanne, Switzerland.
Stéphane KollyGeneral Psychiatry Service, Department of Psychiatry, Lausanne University Clinic and University of Lausanne, Lausanne, Switzerland.

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung SNSF100014_179457/1
6 · The paper itself

Abstract

backgroundBorderline Personality Disorder (BPD) is one of the most frequent, severe, mental conditions and is associated with a serious burden of disease. Treatment for patients with BPD involves structured psychotherapy. In addition and in order to improve access to care, psychiatric treatments are available. So far, it remains unclear if brief psychiatric intervention according to Good Psychiatric Management (GPM) produces a reliable effect on a variety of clinical outcomes. The assessment of mechanisms of change contributes to focus the treatment on the essential ingredients of change. The current study aims to demonstrate the emotional processing as a mechanism of change, assessed in an ecologically valid experimental context, of brief GPM.

methodsThe present two-arm randomized controlled study aims at testing the effects (i.e., reduction in borderline symptoms) and emotional processing as mechanism of change of a brief psychiatric treatment (10 sessions over 4 months), compared with treatment as usual. Participants are N = 76 patients with BPD who are either randomized to a 4 month GPM or a 4 month TAU without any BPD-specific content. All patients undergo assessments of borderline symptoms using ZAN-BPD and experiential enactment for assessment of emotional processing, at intake, 2 months and 4 months (discharge).

resultsThe effect of a brief version of GPM is not different from the effect of TAU on the total score of the ZAN-BPD at 4 month (d = 0.04). At the level of the secondary effects, GPM is more effective in reducing relationship problems on the ZAN-BPD sub-scale (F(1, 61) = 5.53; p = .022, d = 0.52), and in reducing impulsivity and social problems, and it increases treatment retention. Change in emotional processing between intake and month 2 mediates the reduction on the ZAN-BPD subscale relationship problems assessed between months 2 and 4, in an ecologically valid experimental context.

conclusionsOverall, brief GPM is not different from TAU in terms of reduction in borderline symptoms, but it may produce reduction in relationship problems between months 2 and 4 into the brief intervention. Change in emotional processing in an experimental context may function as mechanism of change of brief GPM. This study is in line with the top priority of establishing efficacy of brief interventions for BPD and proposes an evidence-based explanation for efficacy. These results should help disseminate brief psychiatric treatments for BPD, which contribute to reduce the societal burden related with BPD.

trial registrationClinical Trials NCT03717818 (date of registration of Abstract October 24th, 2018). Protocol number 2 from February 9th, 2018.

Indexed as

Borderline Personality DisorderEmotionsAdultFemaleHumansMaleMiddle AgedPsychotherapy, BriefTreatment OutcomeYoung AdultBorderline personality disorderBrief good psychiatric managementEmotional processingMechanisms of changePsychiatric treatmentRandomized controlled trial

Identifiers

PMID39696018
PMCPMC11656953

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.