Evidence map›Paper›PMID 39696234›Full record

ArticleCardiovascular diabetology2024

A comparison between lipid-based vs. glycemic-based insulin sensitivity indices for the association with abnormal ECG findings and 20-year mortality among older adults.

Yonatan Moshkovits, Adam Goldman, Angela Chetrit, Hadar Moshkovitz Shrem, Rachel Dankner

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yonatan MoshkovitsDepartment of Internal Medicine F, Sheba Medical Center, Ramat-Gan, Israel.
Adam GoldmanDepartment of Internal Medicine F, Sheba Medical Center, Ramat-Gan, Israel.
Angela ChetritPublic Health Research Center, the Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, 52621, Ramat Gan, Israel.
Hadar Moshkovitz ShremThe Adelson School of Medicine, Ariel University, Ariel, Israel.
Rachel DanknerDepartment of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Health Sciences and Medicine, Tel Aviv University, Tel Aviv, Israel. rdankner@tauex.tau.ac.il.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA direct comparison between glycemic-based and lipid-based insulin sensitivity indices (ISIs) for ECG findings and all-cause and cardiovascular mortality is lacking.

methods963 community-dwelling older adults, examined as part of the third phase of the Glucose intolerance, Obesity, and Hypertension study between 1999 and 2008, were followed until December 2016 and December 2019 for cardiovascular and all-cause mortality, respectively. Eleven different ISIs were calculated and evaluated against ECG findings, all-cause, and cardiovascular mortality with multivariable regression models. The area under the receiver operating curve (AUC) and net reclassification improvement (NRI) analysis were implemented to compare ISIs performance.

resultsMean age was 72.3 ± 7 years and 471 (49%) were females. Ischemic ECG changes were observed in 107 (11.2%) individuals. Upper quartile (Q

conclusionsTyG-WTHR was the only ISI associated with ischemic changes on ECG and all-cause and cardiovascular mortality and significantly improved the predictive performance for all-cause cardiovascular mortality. While most glycemic-based and lipid-based ISIs showed similar predictive ability, TyG-WTHR stands as the preferred ISI and should be considered for screening at-risk individuals for cardiovascular morbidity and mortality.

Indexed as

BiomarkersBlood GlucoseCardiovascular DiseasesCause of DeathElectrocardiographyInsulin ResistancePredictive Value of TestsAgedAged, 80 and overAge FactorsFemaleHeart Disease Risk FactorsHumansInsulinLipidsMaleBiomarkersBlood GlucoseInsulinLipidsTriglyceridesAll-cause mortalityCardiovascular mortalityECG abnormalitiesInsulin sensitivity indicesIschemic changes

Identifiers

PMID39696234
PMCPMC11656852

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.