Evidence map›Paper›PMID 39696779›Full record

Observational studyTransfusion2025

Plasma transfusion in the intensive care unit.

Maite M T van Haeren, Senta Jorinde Raasveld, Sanne de Bruin, Merijn C Reuland, Claudia van den Oord, Jimmy Schenk, Cécile Aubron, Jan Bakker, Maurizio Cecconi, Aarne Feldheiser and 32 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Maite M T van HaerenDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.ORCID https://orcid.org/0009-0009-2674-0668
Senta Jorinde RaasveldDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Sanne de BruinDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Merijn C ReulandDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.ORCID https://orcid.org/0009-0009-3738-0397
Claudia van den OordDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Jimmy SchenkDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Cécile AubronMédecine Intensive Réanimation, CHU de Brest, Université de Bretagne Occidentale, Brest, France.
Jan BakkerDepartment of Intensive Care Adults, Erasmus MC University Medical Centers, Rotterdam, the Netherlands.
Maurizio CecconiDepartment of Anesthesiology and Intensive Care, IRCCS Humanitas Research Hospital, Milan, Italy.
Aarne FeldheiserDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, Evang. Kliniken Essen-Mitte, Huyssens-Stiftung/Knappschaft, Essen, Germany.
Harm-Jan de GroothDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Jens MeierDepartment of Anesthesiology and Intensive Care, Kepler University Clinic, Linz, Austria.
Thomas W L ScheerenDepartment of Anesthesiology, University Medical Center Groningen, Groningen, the Netherlands.
Zoe McQuiltenSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.ORCID https://orcid.org/0000-0001-9698-7185
Andrew FlintSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.ORCID https://orcid.org/0000-0001-9183-7882
Tarikul HamidDepartment of Critical Care, Asgar Ali Hospital, Dhaka, Bangladesh.
Michaël PiagnerelliDepartment of Intensive Care, CHU Charleroi Marie Curie, Charleroi, Belgium.
Tina Tomić MahečićDepartment of Anesthesiology and Intensive Care, University Clinical Hospital Center Zagreb, Zagreb, Croatia.
Jan BenesDepartment of Anesthesiology and Intensive Care Medicine, University Hospital and Faculty of Medicine in Plzen - Charles University, Plzen, Czech Republic.
Lene RussellDepartment of Intensive Care, Copenhagen University Hospital, Rigshospitalet Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-7352-8728
Hernan Aguirre-BermeoUnidad de Cuidados Intensivos, Hospital Vicente Corral Moscoso, Cuenca, Ecuador.
Konstantina TriantafyllopoulouDepartment of Cardiothoracic Surgery, Interbalkan Medical Center, Thessaloniki, Greece.ORCID https://orcid.org/0009-0008-3039-6727
Vasiliki ChantziaraDepartment of Respiratory Medicine, National and Kapodistrian University of Athens, Sotiria Chest Hospital, Athens, Greece.
Mohan GurjarDepartment of Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Sheila Nainan MyatraDepartment of Anesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.
Vincenzo PotaDepartment of Child, General and Specialistic Surgery, University of Campania, "Luigi Vanvitelli", Naples, Italy.
Muhammed ElhadiFaculty of Medicine, University of Tripoli, Tripoli, Libya.
Ryszard GawdaDepartment of Anesthesiology and Intensive Care, Institute of Medical Sciences, University of Opole, Opole, Poland.
Mafalda MouriscoDepartment of Intensive Care, Centro Hospitalar de Entro o Douro e Vouga, Santa Maria da Feira, Portugal.
Marcus LanceDepartment of Anesthesiology, Aga Khan University Hospital, Nairobi, Kenya.
Vojislava NeskovicDepartment of Anesthesia and Intensive Care, Military Medical Academy Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0003-3583-7129
Matej PodbregarDepartment for Internal Medicine, University of Ljubljana, Ljubljana, Slovenia.
Juan V LlauDepartment of Anesthesiology and Post-surgical Critical Care, University Hospital Doctor Peset, Valencia, Spain.
Manual Quintana-DiazIntensive Care Service, Hospital Universitario La Paz, Madrid, Spain.
Maria CronhjortDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Carmen A PfortmuellerDepartment of Intensive Care, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Nihan YapiciDepartment of Anesthesiology and Reanimation, Dr Siyami Ersek Thoracic and Cardiovascular Surgery Center, University of Health Sciences, Istanbul, Turkey.
Nathan D NielsenDivision of Pulmonary, Critical Care and Sleep Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Akshay ShahNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Alexander P J VlaarDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0002-3453-7186
Marcella C A MüllerDepartment of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
InPUT Study Group

Funding

National Blood Authority of Australia and a National Health and Medical Research Council (NHMRC) Synergy GNT1189490National Health and Medical Research Council (NHMRC) Emerging Leader Investigator GNT1194811ZonMw Vidi 09150172010047
6 · The paper itself

Abstract

backgroundCurrent guidelines discourage prophylactic plasma use in non-bleeding patients. This study assesses global plasma transfusion practices in the intensive care unit (ICU) and their alignment with current guidelines. STUDY DESIGN AND

methodsThis was a sub-study of an international, prospective, observational cohort. Primary outcomes were in-ICU occurrence rate of plasma transfusion, proportion of plasma events of total blood products events, and number of plasma units per event. Secondary outcomes included transfusion indications, INR/PT, and proportion of events for non-bleeding indications.

resultsOf 3643 patients included, 356 patients (10%) experienced 547 plasma transfusion events, accounting for 18% of total transfusion events. A median of 2 (IQR 1, 2) units was given per event excluding massive transfusion protocol (MTP) and 3 (IQR 2, 6) when MTP was activated. MTP accounted for 39 (7%) of events. Indications of non-MTP events included active bleeding (54%), prophylactic (25%), and pre-procedure (12%). Target INR/PT was stated for 43% of transfusion events; pre-transfusion INR/PT or visco-elastic hemostatic assays (VHA) were reported for 73%. Thirty-seven percent of events were administered for non-bleeding indications, 54% with a pre-transfusion INR < 3.0 and 30% with an INR < 1.5. DISCUSSION: Plasma transfusions occurred in 10% of ICU patients. Over a third were given for non-bleeding indications and might have been avoidable. Target INR/PT was not stated in more than half of transfusions, and pre-transfusion INR/PT or VHA was not reported for 27%. Further research and education is needed to optimize guideline implementation and to identify appropriate indications for plasma transfusion.

Indexed as

Blood Component TransfusionIntensive Care UnitsPlasmaAgedFemaleHemorrhageHumansMaleMiddle AgedPractice Guidelines as TopicProspective Studiescritically illICUintensive care unitplasmatransfusiontransfusion practices

Identifiers

PMID39696779
PMCPMC11747124

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.