Evidence map›Paper›PMID 39696904›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2025

Evidence of cortical vascular impairments in early stage of Alzheimer's transgenic mice: Optical imaging.

Hyomin Jeong, Yingtian Pan, Firoz Akhter, Nora D Volkow, Donghui Zhu, Congwu Du

Abstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hyomin JeongDepartment of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA.ORCID 0009-0005-9970-7069
Yingtian PanDepartment of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA.
Firoz AkhterDepartment of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA.
Nora D VolkowNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Donghui ZhuDepartment of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA.
Congwu DuDepartment of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA.

Funding

Novel surface-modified bioresorbable zinc-based stent materialsR01HL140562 · NHLBI · UNIVERSITY OF NORTH TEXAS · PI Ke Cheng, Donghui Zhu · 2018 to 2026
$4.3M
Calcium-related Neurotoxicity of CocaineR01DA029718 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI DU, CONGWU, PAN, YINGTIAN · 2012 to 2025
$4.2M
Molecular Mechanism and Functional Role of Magnesium in Neuroinflammation in Alzheimer's DiseaseR01AG064798 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI ZHU, DONGHUI · 2019 to 2023
$3.6M
Bioresorbable Zinc Staples for Anastomoses in the Digestive TractR01DK129493 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI Donghui Zhu · 2022 to 2026
$3.2M
Neuro-glio-vascular interactions in vivo probed with optical imagingRF1DA048808 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI DU, CONGWU, PAN, YINGTIAN · 2019 to 2019
$1.2M
Imaging neural, astrocytic and vascular synchronization to assess cocaine's effects on mPFCR21DA057699 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI DU, CONGWU, LING, HAIBIN · 2023 to 2024
$416k
NHLBI NIH HHS R01 HL140562NIA NIH HHS R01 AG064798NIDA NIH HHS R01 DA029718NIDA NIH HHS R21 DA057699NIDA NIH HHS RF1 DA048808NIDDK NIH HHS R01 DK129493
6 · The paper itself

Abstract

Alzheimer's disease (AD), a neurodegenerative disorder with progressive cognitive decline, remains clinically challenging with limited understanding of etiology and interventions. Clinical studies have reported vascular defects prior to other pathological manifestations of AD, leading to the "Vascular Hypothesis" for the disorder. However,

Indexed as

Alzheimer DiseaseCerebral CortexCerebrovascular CirculationOptical ImagingAnimalsCocaineDisease Models, AnimalHypercapniaMaleMiceMice, TransgenicTomography, Optical CoherenceCocaineAlzheimer’s diseaseearly diagnosisneurovascular dysfunctionODToptical imaging

Identifiers

PMID39696904
PMCPMC12035375

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.