Evidence mapPaperPMID 39698120Full record

ArticleIEEE open journal of engineering in medicine and biology2025

Synthetic Data Generation via Generative Adversarial Networks in Healthcare: A Systematic Review of Image- and Signal-Based Studies.

Muhammed Halil Akpinar, Abdulkadir Sengur, Massimo Salvi, Silvia Seoni, Oliver Faust, Hasan Mir, Filippo Molinari, U Rajendra Acharya

Abstract read
In one paragraph

Article in IEEE open journal of engineering in medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Muhammed Halil AkpinarVocational School of Technical SciencesIstanbul University-Cerrahpasa 34320 Istanbul Türkiye.ORCID https://orcid.org/0000-0001-7563-0937
Abdulkadir SengurTechnology FacultyFirat University 23119 Elazig Türkiye.ORCID https://orcid.org/0000-0003-1614-2639
Massimo SalviDepartment of Electronics and TelecommunicationsPolitecnico di Torino 10129 Turin Italy.ORCID https://orcid.org/0000-0001-7225-7401
Silvia SeoniDepartment of Electronics and TelecommunicationsPolitecnico di Torino 10129 Turin Italy.ORCID https://orcid.org/0000-0001-5372-2654
Oliver FaustAnglia Ruskin University Cambridge Campus CB1 1PT Cambridge U.K.
Hasan MirAmerican University of Sharjah Sharjah 26666 UAE.ORCID https://orcid.org/0000-0002-6863-3002
Filippo MolinariDepartment of Electronics and TelecommunicationsPolitecnico di Torino 10129 Turin Italy.ORCID https://orcid.org/0000-0003-1150-2244
U Rajendra AcharyaUniversity of Southern Queensland Toowoomba QLD 4300 Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Generative Adversarial Networks (GANs) have emerged as a powerful tool in artificial intelligence, particularly for unsupervised learning. This systematic review analyzes GAN applications in healthcare, focusing on image and signal-based studies across various clinical domains. Following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, we reviewed 72 relevant journal articles. Our findings reveal that magnetic resonance imaging (MRI) and electrocardiogram (ECG) signal acquisition techniques were most utilized, with brain studies (22%), cardiology (18%), cancer (15%), ophthalmology (12%), and lung studies (10%) being the most researched areas. We discuss key GAN architectures, including cGAN (31%) and CycleGAN (18%), along with datasets, evaluation metrics, and performance outcomes. The review highlights promising data augmentation, anonymization, and multi-task learning results. We identify current limitations, such as the lack of standardized metrics and direct comparisons, and propose future directions, including the development of no-reference metrics, immersive simulation scenarios, and enhanced interpretability.

Indexed as

data generationdeep learningGenerative adversarial networks (GANs)medical imagingsignal simulation

Identifiers

PMID39698120
PMCPMC11655107

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.