Evidence map›Paper›PMID 39698280›Full record

ArticleACS pharmacology & translational science2024

Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (

Marco Tarullo, Guillermo Fernandez Rodriguez, Alessia Iaiza, Sara Venezia, Alberto Macone, Alessio Incocciati, Silvia Masciarelli, Marcella Marchioni, Marta Giorgis, Marco Lucio Lolli and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  7. FTO depletion does not alter mbioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Marco TarulloDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, 00185 Rome, Italy.
Guillermo Fernandez RodriguezDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, 00185 Rome, Italy.
Alessia IaizaDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, 00185 Rome, Italy.
Sara VeneziaDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, 00185 Rome, Italy.
Alberto MaconeDepartment of Biochemical Sciences "A. Rossi Fanelli″, Sapienza University of Rome, 00185 Rome, Italy.ORCID https://orcid.org/0000-0003-0455-1400
Alessio IncocciatiDepartment of Biochemical Sciences "A. Rossi Fanelli″, Sapienza University of Rome, 00185 Rome, Italy.
Silvia MasciarelliDepartment of Anatomical, Histological, Forensic & Orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, 00161 Rome, Italy.
Marcella MarchioniInstitute of Biology, Molecular Medicine and Nanobiotechnology, CNR, Sapienza University of Rome, 00185 Rome, Italy.
Marta GiorgisDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.ORCID https://orcid.org/0000-0002-3282-1220
Marco Lucio LolliDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.ORCID https://orcid.org/0000-0002-3030-3163
Federico FornaseriDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Ludovica ProiettiInstitute of Medical Biochemistry, University of Veterinary Medicine, 1210 Vienna, Austria.
Florian GrebienInstitute of Medical Biochemistry, University of Veterinary Medicine, 1210 Vienna, Austria.
Serena RosignoliDepartment of Biochemical Sciences "A. Rossi Fanelli″, Sapienza University of Rome, 00185 Rome, Italy.
Alessandro PaiardiniDepartment of Biochemical Sciences "A. Rossi Fanelli″, Sapienza University of Rome, 00185 Rome, Italy.
Dante RotiliDepartment of Science, Roma Tre University, 00146 Rome, Italy.ORCID https://orcid.org/0000-0002-8428-8763
Antonello MaiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID https://orcid.org/0000-0001-9176-2382
Elena BochenkovaDepartment of Biochemistry, University of Zurich, CH-8057 Zürich, Switzerland.
Amedeo CaflischDepartment of Biochemistry, University of Zurich, CH-8057 Zürich, Switzerland.ORCID https://orcid.org/0000-0002-2317-6792
Francesco FaziDepartment of Anatomical, Histological, Forensic & Orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, 00161 Rome, Italy.
Alessandro FaticaDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, 00185 Rome, Italy.ORCID https://orcid.org/0000-0002-0743-7905

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FTO, an

Identifiers

PMID39698280
PMCPMC11651170

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.