Evidence map›Paper›PMID 39698369›Full record

ArticleKidney international reports2024

Michél Strauss-Kruger, Eric Olinger, Patrick Hofmann, Ian J Wilson, Carina Mels, Ruan Kruger, Lebo F Gafane-Matemane, John A Sayer, Cristian Ricci, Aletta E Schutte and 1 more

Abstract read
In one paragraph

Article in Kidney international reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Michél Strauss-KrugerHypertension in Africa Research Team, North-West University, Potchefstroom, North-West Province, South Africa.
Eric OlingerInstitute of Physiology, University of Zurich, Zurich, Switzerland.
Patrick HofmannInstitute of Physiology, University of Zurich, Zurich, Switzerland.
Ian J WilsonBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Carina MelsHypertension in Africa Research Team, North-West University, Potchefstroom, North-West Province, South Africa.
Ruan KrugerHypertension in Africa Research Team, North-West University, Potchefstroom, North-West Province, South Africa.
Lebo F Gafane-MatemaneHypertension in Africa Research Team, North-West University, Potchefstroom, North-West Province, South Africa.
John A SayerBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Cristian RicciAfrican Unit for Transdisciplinary Health Research, North-West University, Potchefstroom, North-West Province, South Africa.
Aletta E SchutteHypertension in Africa Research Team, North-West University, Potchefstroom, North-West Province, South Africa.
Olivier DevuystInstitute of Physiology, University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Single-nucleotide polymorphisms (SNPs) in the Methods: Clinical parameters, 3 selected Results: Absolute uUMOD and uUMOD/creatinine levels were lower in Black participants compared to White participants. The prime CKD-risk allele at rs12917707 was more prevalent in Black individuals, with strikingly more risk allele homozygotes compared to White individuals. Haplotype analysis of the Conclusion: We evidenced ethnic differences in clinical and genetic determinants of uUMOD levels, in particular an interaction of ethnicity on the relationship between CKD-risk SNPs and uUMOD. These differences should be considered when analyzing the role of uromodulin in kidney function, interpreting genome-wide association studies (GWAS), and precision medicine recommendations.

Indexed as

Africachronic kidney diseaseepidemiologyGWASuromodulin

Identifiers

PMID39698369
PMCPMC11652103

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.