Evidence map›Paper›PMID 39699847›Full record

ArticleJournal of physiology and biochemistry2025

The mechanism of LQTS related CaM mutation E141G interfering with Ca

Chenyang Zhang, Dongxue Shao, Xi Zheng, Liying Hao

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of physiology and biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chenyang Zhang *Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang, 110122, China.
Dongxue Shao *Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang, 110122, China.
Xi ZhengDepartment of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang, 110122, China.
Liying HaoDepartment of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang, 110122, China. lyhao@cmu.edu.cn.

Funding

National Natural Science Foundation of China 31471091the Key Laboratory of Medical Electrophysiology (Southwest Medical University), Ministry of Education of China KeyME-2018-02
6 · The paper itself

Abstract

Mutations in the CALM1-3 genes, which encode calmodulin (CaM), have been reported in clinical cases of long QT syndrome (LQTS). Specifically, the CaM mutant E141G (CaM

Indexed as

Calcium Channels, L-TypeCalmodulinLong QT SyndromeAnimalsCalciumHEK293 CellsHumansMutationCACNA1C protein, humanCalciumCalcium Channels, L-TypeCALM1 protein, humanCalmodulinL-type calcium channel alpha(1C)CalmodulinCaV1.2 channelC-lobeLong QT syndromeMutant E141G

Identifiers

PMID39699847

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.