Evidence map›Paper›PMID 39700009›Full record

ArticleCell reports2025

Pharmacological blocking of spinal GABA

Amr A Mahrous, Lucy Liang, Josep-Maria Balaguer, Jonathan C Ho, Erinn M Grigsby, Vahagn Karapetyan, Arianna Damiani, Daryl P Fields, Jorge A Gonzalez-Martinez, Peter C Gerszten and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Recovery of Dexterous Motor Control via Non-Monosynaptic Corticospinal Pathways.medRxiv : the preprint server for health sciences · 2026
    Article
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Amr A MahrousDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Lucy LiangRehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA.
Josep-Maria BalaguerRehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA.
Jonathan C HoSchool of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Erinn M GrigsbyDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA.
Vahagn KarapetyanRehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA.
Arianna DamianiRehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA.
Daryl P FieldsDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Jorge A Gonzalez-MartinezDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Peter C GersztenDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
David J BennettNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada; Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada.
C J HeckmanDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Physical Medicine and Rehabilitation, Shirley Ryan AbilityLab, Chicago, IL, USA.
Elvira PirondiniRehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: elvirap@pitt.edu.
Marco CapogrossoRehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: mcapo@pitt.edu.

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Motoneuron Properties in Chronic Spinal InjuryR01NS047567 · NINDS · UNIVERSITY OF ALBERTA · PI BENNETT, DAVID JAMES, FOUAD, KARIM · 2004 to 2020
$4.0M
Mechanisms of electrical stimulation of a canonical motor microcircuitR01NS109552 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HECKMAN, CHARLES · 2018 to 2022
$2.5M
Deep brain stimulation of the motor thalamus to improve cortico-spinal control of muscles after strokeR01NS131428 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jorge Alvaro Gonzalez-Martinez, Elvira Pirondini · 2024 to 2026
$1.8M
NIH HHS P51 OD011133NINDS NIH HHS R01 NS047567NINDS NIH HHS R01 NS109552NINDS NIH HHS R01 NS131428
6 · The paper itself

Abstract

A century of research established that GABA inhibits proprioceptive inputs presynaptically to sculpt spinal neural inputs into skilled motor output. Recent results in mice challenged this theory by showing that GABA can also facilitate action potential conduction in proprioceptive afferents. Here, we tackle this controversy in monkeys, the most human-relevant animal model, and show that GABA

Indexed as

GABA-A Receptor AntagonistsReceptors, GABA-ASpinal CordSynaptic TransmissionThalamusAction PotentialsAnimalsgamma-Aminobutyric AcidInterneuronsMaleMotor NeuronsSomatosensory CortexGABA-A Receptor Antagonistsgamma-Aminobutyric AcidReceptors, GABA-ACP: Cell biologyCP: NeuroscienceGABAGABA(A) receptorshandmonkeyspresynaptic inhibitionprimary afferent depolarizationsensory transmissionsomatosensory cortexspinal reflexesthalamus

Identifiers

PMID39700009
PMCPMC12442854

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.