Evidence map›Paper›PMID 39700425›Full record

ArticleBioinformatics (Oxford, England)2024

The FunCoup Cytoscape App: multi-species network analysis and visualization.

Davide Buzzao, Lukas Steininger, Dimitri Guala, Erik L L Sonnhammer

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Exploring the CeRNA landscape in plants: advances, methods, and challenges.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Review
  3. Integrative RNA-seq analysis reveals immune-related hub genesInternational journal of reproductive biomedicine · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Davide BuzzaoDepartment of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, 171 21 Solna, Sweden.ORCID 0000-0002-7521-8368
Lukas SteiningerDepartment of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, 171 21 Solna, Sweden.
Dimitri GualaDepartment of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, 171 21 Solna, Sweden.ORCID 0000-0003-2245-7557
Erik L L SonnhammerDepartment of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, 171 21 Solna, Sweden.ORCID 0000-0002-9015-5588

Funding

Swedish Research Council 2019-04095
6 · The paper itself

Abstract

motivationFunctional association networks, such as FunCoup, are crucial for analyzing complex gene interactions. To facilitate the analysis and visualization of such genome-wide networks, there is a need for seamless integration with powerful network analysis tools like Cytoscape.

resultsThe FunCoup Cytoscape App integrates the FunCoup web service API with Cytoscape, allowing users to visualize and analyze gene interaction networks for 640 species. Users can input gene identifiers and customize search parameters, using various network expansion algorithms like group or independent gene search, MaxLink, and TOPAS. The app maintains consistent visualizations with the FunCoup website, providing detailed node and link information, including tissue and pathway gene annotations. The integration with Cytoscape plugins, such as ClusterMaker2, enhances the analytical capabilities of FunCoup, as exemplified by the identification of the Myasthenia gravis disease module along with potential new therapeutic targets. AVAILABILITY AND IMPLEMENTATION: The FunCoup Cytoscape App is developed using the Java OSGi framework, with UI components implemented in Java Swing and build support from Maven. The App is available as a JAR file at https://bitbucket.org/sonnhammergroup/funcoup_cytoscape/ repository, and can be downloaded from the Cytoscape App store https://apps.cytoscape.org/apps/funcoup.

Indexed as

AlgorithmsGene Regulatory NetworksSoftwareComputational BiologyHumans

Identifiers

PMID39700425
PMCPMC11684335

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.