Evidence map›Paper›PMID 39700460›Full record

ArticleOrganic letters2025

An Improved P(V) Thio-Oligonucleotide Synthesis Platform.

Molhm Nassir, Luca Gherardi, Richard L Redman, Yonghao Jin, Feng Yao, Yang Yang, Nicholas Raheja, Arjun Natarajan, David Butler, Kyle W Knouse and 1 more

Abstract read
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Molhm NassirDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Luca GherardiDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Richard L RedmanElsie Biotechnologies Inc, San Diego, California 92121, United States.ORCID 0000-0002-7091-0988
Yonghao JinElsie Biotechnologies Inc, San Diego, California 92121, United States.
Feng YaoShanghai Hongene Biotech Corporation, No. 60 Bei Shagang Road, Minhang District, Shanghai 201108, China.
Yang YangShanghai Hongene Biotech Corporation, No. 60 Bei Shagang Road, Minhang District, Shanghai 201108, China.
Nicholas RahejaDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Arjun NatarajanSocrates Biosciences Inc, 760 Calle Plano, Camarillo, California 93012, United States.
David ButlerHongene Biotech Corporation, 29520 Kohoutek Way, Union City, California 94587, United States.
Kyle W KnouseElsie Biotechnologies Inc, San Diego, California 92121, United States.
Phil S BaranDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0001-9193-9053

Funding

Scalable Synthesis and New Bond DisconnectionsR35GM118176 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI BARAN, PHIL S · 2016 to 2025
$11.5M
NIGMS NIH HHS R35 GM118176
6 · The paper itself

Abstract

Three critical advances in simplifying the adoption of P(V)-based stereopure, phosphorothioate-containing oligonucleotide synthesis are reported. A more inexpensive phosphorus-sulfur incorporation reagent (

Indexed as

OligonucleotidesBromineMolecular StructurePhosphorothioate OligonucleotidesPhosphorusStereoisomerismSulfurBromineOligonucleotidesPhosphorothioate OligonucleotidesPhosphorusSulfur

Identifiers

PMID39700460
PMCPMC11723805

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.