Evidence map›Paper›PMID 39701467›Full record

Trial reportJournal of affective disorders2025

Rumination induction task in fMRI: Effects of rumination focused cognitive behavioral therapy and stability in youth.

Mindy Westlund Schreiner, Anna M Jacobsen, Brian W Farstead, Raina H Miller, Rachel H Jacobs, Leah R Thomas, Katie L Bessette, Myah Pazdera, Sheila E Crowell, Erin A Kaufman and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of affective disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Neural Circuit Taxonomy and Precision Psychiatry in Major Depression.Advances in experimental medicine and biology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mindy Westlund SchreinerBehavioral Health, Nationwide Children's Hospital, Columbus, OH, USA; Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH, USA; Department of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, USA. Electronic address: mindy.westlundschreiner@nationwidechildrens.org.
Anna M JacobsenDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, USA; Department of Adult Psychiatry and Psychotherapy, University of Zurich, Zurich, CH, Switzerland; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.
Brian W FarsteadDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, USA; Department of Psychology, University of Southern Mississippi, Hattiesburg, MS, USA.
Raina H MillerDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, USA; Morgridge College of Education, University of Denver, Denver, CO, USA.
Rachel H JacobsDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Leah R ThomasDepartment of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH, USA; Department of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, USA.
Katie L BessetteDepartment of Psychiatry & Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA; Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.
Myah PazderaDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, USA.
Sheila E CrowellDepartment of Psychology, University of Oregon, Eugene, OR, USA.
Erin A KaufmanDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, USA.
Daniel A FeldmanDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, USA; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA; Department of Radiology, University of Utah, Salt Lake City, UT, USA.
Henrietta RobertsSchool of Psychology, University of Exeter, Exeter, UK.
Robert C WelshDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, USA; Department of Psychiatry & Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA; Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.
Edward R WatkinsSchool of Psychology, University of Exeter, Exeter, UK.
Scott A LangeneckerBehavioral Health, Nationwide Children's Hospital, Columbus, OH, USA; Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH, USA; Department of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, USA.

Funding

Developing rumination-focused treatment to reduce risk for depression recurrence (RDR) in adolescenceR33MH116080 · NIMH · UNIVERSITY OF UTAH · PI LANGENECKER, SCOTT A, WATKINS, EDWARD · 2022 to 2024
$2.7M
Developing rumination-focused treatment to reduce risk for depression recurrence (RDR) in adolescenceR61MH116080 · NIMH · UNIVERSITY OF UTAH · PI LANGENECKER, SCOTT A, WATKINS, EDWARD · 2018 to 2019
$1.8M
Examining Mechanisms of Change in Adolescent Self-Inflicted InjuryK23MH135225 · NIMH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Erin Anne Kaufman · 2024 to 2026
$598k
NIMH NIH HHS K23 MH135225NIMH NIH HHS R33 MH116080NIMH NIH HHS R61 MH116080
6 · The paper itself

Abstract

backgroundRumination is implicated in the onset and maintenance of major depressive disorder (MDD). Rumination-Focused Cognitive Behavioral Therapy (RF-CBT) effectively targets rumination and may change resting-state brain connectivity and change in activation during a rumination induction task (RIT) post-intervention predicts depressive symptoms two years later. We examined brain activation changes during an RIT in adolescents with remitted MDD following RF-CBT and evaluated RIT reliability (or stability) during treatment as usual (TAU).

methodFifty-five adolescents ages 14-17 completed an RIT at baseline, were randomized to 10-14 sessions of RF-CBT (n = 30) or treatment as usual (n = 25) and completed an RIT at post-treatment or equivalent time delay. The RIT includes recalling negative memories (Rumination Instruction), dwelling on their meaning/consequences (Rumination Prompt), and imagining unrelated scenes and objects (Distraction). We assessed activation change in the RF-CBT group using paired-samples t-tests. We assessed reliability (or stability) via intraclass correlation coefficients (ICCs) of five rumination-related ROIs for TAU and RF-CBT separately across task blocks.

resultsFollowing treatment, participants receiving RF-CBT demonstrated increased activation of left precuneus during Rumination Instruction and of left angular and superior temporal gyri during Rumination Prompt blocks (p < .01). From baseline to post-treatment, across most ROIs and task blocks, the RF-CBT group demonstrated poor stability (M = 0.21, range = -0.19-0.69), while the TAU group demonstrated fair-to-excellent stability (M = 0.52, range = 0.27-0.86).

conclusionRF-CBT changes activation of rumination-related circuitry during state-induced rumination, offering exciting avenues for future interventions. The RIT has fair-to-excellent stability among individuals not explicitly treated for rumination, and as expected, RIT stability is disrupted by RF-CBT.

Indexed as

BrainCognitive Behavioral TherapyMajor Depressive DisorderRumination, CognitiveAdolescentFemaleHumansMagnetic Resonance ImagingMaleAdolescenceNeuroimagingReliabilityRuminationStabilityTherapy

Identifiers

PMID39701467
PMCPMC12053545

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.