Evidence map›Paper›PMID 39702006›Full record

ArticleBMC genomics2024

Linking the gut microbiome to host DNA methylation by a discovery and replication epigenome-wide association study.

Ayşe Demirkan, Jenny van Dongen, Casey T Finnicum, Harm-Jan Westra, Soesma Jankipersadsing, Gonneke Willemsen, Richard G Ijzerman, Dorret I Boomsma, Erik A Ehli, Marc Jan Bonder and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ayşe DemirkanDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. a.demirkan@surrey.ac.uk.
Jenny van DongenBiological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Casey T FinnicumAvera Institute of Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, Sioux Falls, SD, USA.
Harm-Jan WestraDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Soesma JankipersadsingDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Gonneke WillemsenBiological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Richard G IjzermanDepartment of Endocrinology, Amsterdam University Medical Center, location AMC, Amsterdam, the Netherlands.
Dorret I BoomsmaAmsterdam Public Health Research Institute, Amsterdam MC, Amsterdam, the Netherlands.
Erik A EhliAvera Institute of Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, Sioux Falls, SD, USA.
Marc Jan BonderDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Jingyuan FuDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Lude FrankeDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Cisca WijmengaDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Eco J C de GeusBiological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Alexander KurilshikovDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Alexandra ZhernakovaDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. sashazhernakova@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbiome influences multiple human systems, but its effects on gene methylation is unknown. We investigated the relations between gene methylation in blood and the abundance of common gut bacteria profiled by 16s rRNA gene sequencing in two population-based Dutch cohorts: LifeLines-Deep (LLD, n = 616, discovery) and the Netherlands Twin Register (NTR, n = 296, replication). In LLD, we also explored microbial pathways using data generated by shotgun metagenomic sequencing (n = 683). Methylation in both cohorts was profiled in blood samples using the Illumina 450K array. Discovery and replication analysis identified two independent CpGs associated with the genus Eggerthella: cg16586104 (P

Indexed as

DNA MethylationEpigenomeGastrointestinal MicrobiomeGenome-Wide Association StudyAdultCpG IslandsFemaleHumansMaleMiddle AgedNetherlandsRNA, Ribosomal, 16SRNA, Ribosomal, 16S16s rRNADNA methylationGut microbiomeHost gene methylationShotgun-metagenomics

Identifiers

PMID39702006
PMCPMC11660878

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.