Evidence map›Paper›PMID 39702144›Full record

ReviewCancer cell international2024

HOTAIR in cancer: diagnostic, prognostic, and therapeutic perspectives.

Majid Nazari, Emad Babakhanzadeh, Arghavan Mollazadeh, Mohadese Ahmadzade, Elham Mohammadi Soleimani, Elnaz Hajimaqsoudi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer cell international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  4. Exosomal lncRNAsInternational journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Majid NazariDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, P.O. Box 64155-65117, Tehran, Yazd, Iran. Vision.nazari@gmail.com.
Emad BabakhanzadehDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Arghavan MollazadehDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL, 60115, USA.
Mohadese AhmadzadeDepartment of Urology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Elham Mohammadi SoleimaniDepartment of Medical Microbiology, Kerman University of Medical Science, Kerman, Iran.
Elnaz HajimaqsoudiDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The long non-coding RNA HOTAIR is overexpressed in many cancers and is associated with several cancer-promoting effects, including increased cell proliferation, migration and treatment resistance. HOTAIR levels correlate with tumor stage, lymph node metastasis and overall survival in patients with various types of cancer. This highlights the potential uses of HOTAIR, including early cancer detection, predicting patient outcome, identifying high-risk individuals and assisting in therapy selection and monitoring. The aim of this review is to provide a comprehensive summary of the research progress, molecular mechanisms and clinical significance of HOTAIR in various human cancers. In addition, the clinical applications of HOTAIR, such as targeted therapy, radiotherapy, chemotherapy and immunotherapy, are discussed, and relevant information on the potential future advances of HOTAIR in cancer research is provided.

Indexed as

BiomarkerCancerChemotherapyHOTAIRImmunotherapyRadiotherapy

Identifiers

PMID39702144
PMCPMC11660992

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.