Evidence map›Paper›PMID 39702549›Full record

ArticleArthritis research & therapy2024

Neutrophil extracellular traps and oxidative stress in systemic lupus erythematosus patients with and without renal involvement.

Lu Liu, Karina de Leeuw, Harry van Goor, Berber Doornbos-van der Meer, Suzanne Arends, Johanna Westra

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07721857 (Dynamic Changes of Neutrophil Extracellular Traps in Lupus Nephritis and Their Role in Predicting Treatment Response.), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07721857 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Dynamic Changes of Neutrophil Extracellular Traps in Lupus Nephritis and Their Role in Predicting Treatment Response.

TypeobservationalSponsorAssiut UniversityRan2026 to 2028Enrolled100ConditionsLupus Nephritis (LN)ArmsSerum Neutrophil Extracellular Traps
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lu LiuDepartment of Rheumatology and Clinical Immunology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, Groningen, 9700 RB, The Netherlands.
Karina de LeeuwDepartment of Rheumatology and Clinical Immunology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, Groningen, 9700 RB, The Netherlands.
Harry van GoorDepartment of Pathology and Medical Biology, University Medical Centre Groningen, Groningen, The Netherlands.
Berber Doornbos-van der MeerDepartment of Rheumatology and Clinical Immunology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, Groningen, 9700 RB, The Netherlands.
Suzanne ArendsDepartment of Rheumatology and Clinical Immunology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, Groningen, 9700 RB, The Netherlands.
Johanna WestraDepartment of Rheumatology and Clinical Immunology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, Groningen, 9700 RB, The Netherlands. johanna.westra@umcg.nl.

Funding

Chinese Scholarship Council 202006170049
6 · The paper itself

Abstract

objectivesTo investigate the levels of plasma neutrophil extracellular traps (NETs) and free thiols, the latter reflecting systemic oxidative stress (OS), and to explore the relationship between NETs and OS in quiescent systemic lupus erythematosus (SLE) patients with and without renal involvement.

methodsPlasma levels of NETs and free thiols were measured cross-sectionally in 100 SLE patients with low disease activity (SLEDAI < 5), of whom 73 patients had no renal involvement (non-LN) and 27 patients had lupus nephritis (LN). Additionally, 22 healthy controls (HCs) were included. NETs were measured using a myeloperoxidase-DNA complex ELISA and free thiols were measured using a thiol assay kit.

resultsNETs levels were significantly higher in both non-LN and LN patients compared to HCs (p < 0.001, p = 0.013), with no difference between the two patient groups (p = 0.799). Free thiol levels were not significantly different between groups. Interestingly, NETs were negatively correlated with free thiols in all 100 SLE patients (rho = -0.32) and non-LN patients (rho = -0.38), but not in LN patients. Levels of free thiols were significantly lower in subgroups of patients with estimated glomerular filtration rate (eGFR) < 60, serum creatinine (sCr) ≥ 90, C reactive protein (CRP) levels ≥ 5 and body mass index (BMI) ≥ 30. In multivariable regression, disease duration, NETs levels, and eGFR were independently associated with free thiol levels.

conclusionsLevels of NETs were increased in quiescent SLE patients. Although free thiol levels did not differ among the groups. The levels of NETs and free thiols were independently associated in SLE patients, suggesting a potential role of OS in NETs formation. Therefore, reducing OS might be an additional therapeutic target for SLE treatment.

Indexed as

Extracellular TrapsLupus Erythematosus, SystemicLupus NephritisOxidative StressAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedSulfhydryl CompoundsYoung AdultSulfhydryl CompoundsFree thiolsLupus nephritisNeutrophil extracellular trapsOxidative stressSystemic lupus erythematosus

Identifiers

PMID39702549
PMCPMC11658285

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.