Evidence map›Paper›PMID 39702721›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

ncRNA Editing: Functional Characterization and Computational Resources.

Gioacchino P Marceca, Giulia Romano, Mario Acunzo, Giovanni Nigita

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gioacchino P MarcecaIndependent Researcher, Vittoria, RG, Italy.
Giulia RomanoDivision of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Mario AcunzoDivision of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Giovanni NigitaDepartment of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA. Giovanni.Nigita@osumc.edu.

Funding

The Role of Non-Coding RNA Editing in MET Signaling in NSCLCR21CA277525 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI ACUNZO, MARIO · 2023 to 2024
$403k
isomiRGate: a comprehensive gateway for studying the canonical and modified microRNAomes in CancerR21CA287180 · NCI · OHIO STATE UNIVERSITY · PI NIGITA, GIOVANNI · 2024 to 2024
$390k
NCI NIH HHS R21 CA277525NCI NIH HHS R21 CA287180
6 · The paper itself

Abstract

Non-coding RNAs (ncRNAs) play crucial roles in gene expression regulation, translation, and disease development, including cancer. They are classified by size in short and long non-coding RNAs. This chapter focuses on the functional implications of adenosine-to-inosine (A-to-I) RNA editing in both short (e.g., miRNAs) and long ncRNAs. RNA editing dynamically alters the sequence and structure of primary transcripts, impacting ncRNA biogenesis and function. Notable findings include the role of miRNA editing in promoting glioblastoma invasiveness, characterizing RNA editing hotspots across cancers, and its implications in thyroid cancer and ischemia. This chapter also highlights bioinformatics resources and next-generation sequencing (NGS) technologies that enable comprehensive ncRNAome studies and genome-wide RNA editing detection. Dysregulation of RNA editing machinery has been linked to various human diseases, emphasizing the potential of RNA editing as a biomarker and therapeutic target. This overview integrates current knowledge and computational tools for studying ncRNA editing, providing insights into its biological significance and clinical applications.

Indexed as

Computational BiologyRNA EditingRNA, UntranslatedAdenosineAnimalsHigh-Throughput Nucleotide SequencingHumansInosineMicroRNAsNeoplasmsRNA, Long NoncodingAdenosineInosineMicroRNAsRNA, Long NoncodingRNA, Untranslated3′UTRA-to-I RNA editingBioinformaticsDatabasesIntronslncRNAmiRNAncRNA editingNGS

Identifiers

PMID39702721

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.