Evidence map›Paper›PMID 39702860›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Transplantation of Islet Organoids into Brown Adipose Tissue in a Diabetic Mouse Model.

Aixia Sun, Mankirat Singh, Manvir Bamrah, Wen Li, Aitor Aguirre, Ping Wang

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aixia SunPrecision Health Program, Michigan State University, East Lansing, MI, USA.
Mankirat SinghPrecision Health Program, Michigan State University, East Lansing, MI, USA.
Manvir BamrahPrecision Health Program, Michigan State University, East Lansing, MI, USA.
Wen LiInstitute for Quantitative Health Science and Engineering (IQ), Michigan State University, East Lansing, MI, USA.
Aitor AguirreInstitute for Quantitative Health Science and Engineering (IQ), Michigan State University, East Lansing, MI, USA.
Ping WangPrecision Health Program, Michigan State University, East Lansing, MI, USA. wangpin4@msu.edu.

Funding

National Science Foundation 2306708
6 · The paper itself

Abstract

Pancreatic islet transplantation is a promising cell replacement therapy for patients with type 1 diabetes (T1D), an autoimmune disease that destroys insulin-producing islet β cells. However, the shortage of donor pancreatic islets significantly limits the widespread use of this strategy as a routine therapy. Pluripotent stem cell-derived insulin-producing islet organoids present a promising alternative β cell source for T1D patients. One critical challenge is the lack of vascularization in islet organoids, making it essential to investigate vascularized transplantation sites to support their survival. Brown adipose tissue (BAT) is well vascularized and secretes active cytokines, facilitating islet organoid survival. Thus, BAT represents a promising transplantation site for islet organoids, making it an ideal location to support cell replacement therapies and improve treatment approaches for T1D. Here, we describe the methods for transplanting human-induced pluripotent stem cell (iPSC)-derived islet organoids into the BAT of a mouse model.

Indexed as

Adipose Tissue, BrownDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Islets of LangerhansIslets of Langerhans TransplantationOrganoidsAnimalsDisease Models, AnimalHumansInduced Pluripotent Stem CellsInsulin-Secreting CellsMiceBrown adipose tissue (BAT)Islet organoidsIslet organoids transplantationPluripotent stem cellStem cell differentiationType 1 diabetesβ cells

Identifiers

PMID39702860

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.