Evidence map›Paper›PMID 39703023›Full record

ArticleACS synthetic biology2025

Restructuring a Complex Genetic Function on Episomal Vectors in

Andreas B Bertelsen, Anja K Ehrmann, Carolyn Bayer, Tanveer S Batth, Jesper V Olsen, Morten H H Nørholm

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andreas B BertelsenThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby 2800, Denmark.
Anja K EhrmannThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby 2800, Denmark.
Carolyn BayerThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby 2800, Denmark.ORCID 0000-0002-2132-0121
Tanveer S BatthThe Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen N 2200, Denmark.
Jesper V OlsenThe Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen N 2200, Denmark.ORCID 0000-0002-4747-4938
Morten H H NørholmThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby 2800, Denmark.ORCID 0000-0002-7871-5191

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic functions have evolved over long timescales and can be encoded by multiple genes dispersed in different locations in genomes, and although contemporary molecular biology enables control over single genes, more complex genetic functions remain challenging. Here, we study the restructuring and mobilization of a complex genetic function encoded by 10 genes, originally expressed from four operons and two loci on the

Indexed as

Escherichia coliGenetic VectorsPlasmidsGene EditingGenome, BacterialMutationOperonadaptive laboratory evolution (ALE)E. coligenome engineeringiModulonsmetabolic engineeringPseudomonas putida

Identifiers

PMID39703023
PMCPMC11745164

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.