Evidence map›Paper›PMID 39704085›Full record

Trial reportNutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition2025

A liberalized diet does not improve caloric intake during neutropenia in patients undergoing hematopoietic stem cell transplants: A prospective randomized controlled trial.

Jenna N Schulz, Kristina H McGee, Michael T Weaver, John R Wingard, Precious D Williams, Christina L Cline, Nosha Farhadfar, Debra Lynch-Kelly, Zeina A Al-Mansour, Wendy J Dahl

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jenna N SchulzDepartment of Food and Nutrition Services, University of Florida Health Shands Hospital, Gainesville, Florida, USA.
Kristina H McGeeDepartment of Food and Nutrition Services, University of Florida Health Shands Hospital, Gainesville, Florida, USA.
Michael T WeaverCollege of Nursing, University of Florida, Gainesville, Florida, USA.
John R WingardDivision of Hematology/Oncology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Precious D WilliamsDivision of Hematology/Oncology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Christina L ClineDivision of Hematology/Oncology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Nosha FarhadfarDivision of Hematology/Oncology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Debra Lynch-KellyCollege of Nursing, University of Florida, Gainesville, Florida, USA.
Zeina A Al-MansourDivision of Hematology/Oncology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Wendy J DahlDepartment of Food Science and Human Nutrition, University of Florida/IFAS, Gainesville, Florida, USA.ORCID http://orcid.org/0000-0003-2061-4731

Funding

University of Florida
6 · The paper itself

Abstract

backgroundThe neutropenic diet has been a long-standing approach to preventing infection in patients with hematopoietic stem cell transplants (HSCTs), although data on its efficacy are inconclusive and its restrictive nature might contribute to harm by reducing dietary intake in this patient population who typically experiences poor oral intake. The aim was to determine if a liberalized diet (LD), in comparison with a neutropenic hospital diet (ND), would improve energy intake and lessen weight loss during neutropenia in patients with HSCTs.

methodsA randomized controlled trial was conducted in a single-center HSCT/hematologic malignancy unit. The diet interventions were initiated when absolute neutrophil counts dropped to <500 cells/mm

resultsMeal intake compliance (consuming at least 50% of meals/day) was not different between groups (LD, 47%; ND, 43%; P = 0.66). Of the 191 patients assessed (LD, n = 92; ND, n = 99), mean (SD) energy, 678 (349) vs 724 (393) kcal/d (P = 0.46), and protein, 30.3 (18.5) vs 30.4 (18.1) g/day (P = 0.89) did not differ between groups nor did weight change, 0.3 (2.5) vs 1.2 (4.1) kg (P = 0.22) during neutropenia. None vs higher than or equal to grade 1 mucositis, allogeneic vs autologous stem cell transplantation, and fewer days on intervention favored higher energy and protein intakes.

conclusionEnergy intake during neutropenia did not improve with a LD encouraging fresh fruits and vegetables. Thus, alternative approaches to improving dietary intake, such as energy-dense and nutrient-dense foods with sensory characteristics acceptable to patients experiencing significant mucositis, require exploration.

Indexed as

DietEnergy IntakeHematopoietic Stem Cell TransplantationNeutropeniaAdultAgedDietary ProteinsFemaleHumansMaleMiddle AgedProspective StudiesWeight LossDietary Proteinsadulthematopoietic/stem cell transplantlife cycleneutropenic dietoncologyresearch and diseasesweight loss

Identifiers

PMID39704085
PMCPMC12049570

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.