Evidence map›Paper›PMID 39704332›Full record

ArticleMovement disorders clinical practice2025

Parasympathetic Dysfunction Prevails in GBA1-Associated Parkinson's Disease.

Tiziana De Santis, Antoniangela Cocco, Paolo Castiglioni, Maurizio Ferrarin, Rossana Mineri, Emanuela Morenghi, Micol Avenali, Alberto Albanese

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tiziana De SantisDepartment of Neurology, IRCCS Humanitas Research Hospital, Rozzano, Italy.ORCID https://orcid.org/0000-0001-7591-7428
Antoniangela CoccoDepartment of Neurology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Paolo CastiglioniDepartment of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
Maurizio FerrarinIRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Rossana MineriDepartment of Laboratory Medicine, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Emanuela MorenghiBiostatistics Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Micol AvenaliDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Alberto AlbaneseDepartment of Neurology, IRCCS Humanitas Research Hospital, Rozzano, Italy.ORCID https://orcid.org/0000-0002-5864-0006

Funding

Cariplo 2014-0832MNESYS PE0000006
6 · The paper itself

Abstract

backgroundThe role played by sympathetic and parasympathetic autonomic branches in patients with Parkinson's disease carrying variants in the GBA1 gene (GBA-PD) is still elusive.

objectivesTo characterize cardiovascular autonomic function in GBA-PD and I-PD patients with early and mid-stage disease.

methodsThese assessments were performed: cardiovascular autonomic tests, analysis of heart rate and blood pressure variability, cardiac noradrenergic imaging. The frequency and severity of autonomic symptoms were comparatively assessed with the SCOPA-AUT questionnaire.

resultsCompared to the I-PD cohort, GBA-PD patients displayed an increased burden of autonomic symptoms. Autonomic tests revealed worse parasympathetic scores in GBA-PD while sympathetic indexes and the degree of cardiac sympathetic binding were comparable in the two groups. Heart rate variability indexes also revealed lower vagal modulation in the GBA-PD group.

conclusionsThe cardiovascular autonomic profile in GBA PD is characterized by a prominent cardiovagal dysfunction compared to I-PD.

Indexed as

Autonomic Nervous System DiseasesGlucosylceramidaseParasympathetic Nervous SystemParkinson DiseaseAgedBlood PressureFemaleHeart RateHumansMaleMiddle AgedGBA protein, humanGlucosylceramidasedysautonomiaglucocerebrosidasenon‐motor symptomsParkinson's disease

Identifiers

PMID39704332
PMCPMC11952954

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.