Evidence map›Paper›PMID 39704362›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2025

Effects of a Physical Activity Intervention on Perceived Stress, Fatigue, and Depressive Symptoms in Older Adults: A Secondary Analysis of the LIFE Study.

Emily J Smail, Christopher N Kaufmann, Abby C King, Mark A Espeland, Stephen Anton, Todd M Manini

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emily J SmailDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA.
Christopher N KaufmannDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA.
Abby C KingDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California, USA.
Mark A EspelandDivision of Gerontology and Geriatric Medicine, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.ORCID 0000-0002-3711-1949
Stephen AntonDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, Florida, USA.
Todd M ManiniDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA.

Funding

Physical Exercise to Prevent Disability Pilot StudyU01AG022376 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2003 to 2005
$10.9M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · 2022 to 2025
$4.3M
Sleep apnea treatment and risk for cognitive decline and Alzheimers diseaseR01AG079391 · UNIVERSITY OF FLORIDA · 2025 to 2025
$609k
Translational Research Training on Aging and Mobility (TRAM)T32AG062728 · UNIVERSITY OF FLORIDA · 2025 to 2025
$351k
Sedative-Hypnotic Use Patterns and Risk for Cognitive Decline and Alzheimer's DiseaseK01AG061239 · NIA · UNIVERSITY OF FLORIDA · PI Christopher Norfleet Kaufmann · 2023 to 2023
$128k
NIA NIH HHS K01 AG061239NIA NIH HHS P30 AG028740NIA NIH HHS R01 AG079391NIA NIH HHS T32 AG062728NIA NIH HHS U01 AG022376NIH HHS T32AG062728Sleep Research Society Foundation 23-FRA-001
6 · The paper itself

Abstract

backgroundEngaging in physical activity is critical for maintaining well-being in older adults, particularly those at heightened risk for mobility disability. We assessed the effects of a physical activity (PA) intervention on perceived stress, fatigue, and depressive symptoms compared to a health education (HE) program in older adults with mobility challenges and evaluated differential effects of the interventions among those with the poorest self-rated mental health at baseline.

methodsSecondary data analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study, a single-blinded, parallel randomized controlled trial conducted between February 2010 and December 2013. The PA intervention included walking, strength exercises, balance training, and flexibility activities. The HE intervention consisted of workshops on health topics for older adults. The main outcomes for our analysis included standardized scales with participants self-reporting their stress, fatigue, and depressive symptoms at baseline, 12 months, and 24 months postrandomization.

resultsResults from the 1 495 participants (Mage = 78 years; 66% female in both groups) showed no significant between-group differences in perceived stress, fatigue, or depressive symptom scores over time. However, in both intervention groups, participants with worse baseline scores showed a steady improvement in symptom scores over time compared to the remaining participants, who showed some decline (p value for interaction < .05).

conclusionsAmong mobility-impaired individuals, a long-duration, group-based PA intervention had no more impact on stress, fatigue, or depressive symptoms compared to a group-based HE intervention. However, participants with higher symptoms at baseline showed improvement over time in both intervention groups.

Indexed as

DepressionExerciseFatigueStress, PsychologicalAgedAged, 80 and overFemaleHealth EducationHumansMaleSingle-Blind MethodMental healthPhysical activityStress

Identifiers

PMID39704362
PMCPMC11756278

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.