Evidence map›Paper›PMID 39704443›Full record

ArticleAutism : the international journal of research and practice2025

Pre-trained artificial intelligence language model represents pragmatic language variability central to autism and genetically related phenotypes.

Joseph Cy Lau, Emily Landau, Qingcheng Zeng, Ruichun Zhang, Stephanie Crawford, Rob Voigt, Molly Losh

Abstract read
In one paragraph

Article in Autism : the international journal of research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joseph Cy LauNorthwestern University, USA.
Emily LandauNorthwestern University, USA.
Qingcheng ZengNorthwestern University, USA.
Ruichun ZhangNorthwestern University, USA.
Stephanie CrawfordNorthwestern University, USA.
Rob VoigtNorthwestern University, USA.
Molly LoshNorthwestern University, USA.ORCID 0000-0002-9823-8249

Funding

A Family-Genetic Study of Autism and Fragile X SyndromeR01MH091131 · NIMH · NORTHWESTERN UNIVERSITY · PI Molly C Losh · 2012 to 2026
$10.1M
A Family-Genetic Study of Language in AutismR01DC010191 · NIDCD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Molly C Losh · 2010 to 2026
$7.8M
The Role of Context in the Neural Processing of Speech in Autism Spectrum DisorderR21DC022031 · NIDCD · NORTHWESTERN UNIVERSITY · PI Chung Yin Joseph Lau · 2024 to 2026
$600k
Mechanistic underpinnings of pragmatics in ASD: Insights from FMR1-mutation conditionsR03DC021846 · NIDCD · NORTHWESTERN UNIVERSITY · PI LOSH, MOLLY C · 2024 to 2024
$160k
Novel Computational Analysis of Prosody in ASD and the Broad Autism PhenotypeR03DC018644 · NIDCD · NORTHWESTERN UNIVERSITY · PI LOSH, MOLLY C · 2020 to 2021
$149k
NIDCD NIH HHS R01 DC010191NIDCD NIH HHS R03 DC018644NIDCD NIH HHS R03 DC021846NIDCD NIH HHS R21 DC022031NIMH NIH HHS R01 MH091131
6 · The paper itself

Abstract

Many individuals with autism experience challenges using language in social contexts (i.e., pragmatic language). Characterizing and understanding pragmatic variability is important to inform intervention strategies and the etiology of communication challenges in autism; however, current manual coding-based methods are often time and labor intensive, and not readily applied in ample sample sizes. This proof-of-concept methodological study employed an artificial intelligence pre-trained language model, Bidirectional Encoder Representations from Transformers, as a tool to address such challenges. We applied Bidirectional Encoder Representations from Transformers to computationally index pragmatic-related variability in autism and in genetically related phenotypes displaying pragmatic differences, namely, in parents of autistic individuals, fragile X syndrome, and

Indexed as

Artificial IntelligenceAutistic DisorderLanguageAdultFemaleFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeHumansMalePhenotypeFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1artificial intelligenceautismbroad autism phenotypeFMR1 premutationfragile Xpragmatic languagepre-trained language model

Identifiers

PMID39704443
PMCPMC12040583

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.