Evidence map›Paper›PMID 39704728›Full record

ArticleeLife2024

A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit.

Jun Sun, Francisca Rojo-Cortes, Suzana Ulian-Benitez, Manuel G Forero, Guiyi Li, Deepanshu N D Singh, Xiaocui Wang, Sebastian Cachero, Marta Moreira, Dean Kavanagh and 3 more

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jun SunBirmingham Centre for Neurogenetics, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Francisca Rojo-CortesBirmingham Centre for Neurogenetics, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.ORCID https://orcid.org/0000-0003-2332-8423
Suzana Ulian-BenitezBirmingham Centre for Neurogenetics, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Manuel G ForeroSemillero Lún, Grupo D+Tec, Universidad de Ibagué, Ibagué, Colombia.ORCID https://orcid.org/0000-0001-9972-8621
Guiyi LiBirmingham Centre for Neurogenetics, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.ORCID https://orcid.org/0000-0001-9620-5139
Deepanshu N D SinghBirmingham Centre for Neurogenetics, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Xiaocui WangBirmingham Centre for Neurogenetics, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Sebastian CacheroMRC LMB, Cambridge, United Kingdom.
Marta MoreiraBirmingham Centre for Neurogenetics, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.ORCID https://orcid.org/0000-0002-4779-4077
Dean KavanaghInstitute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom.
Gregory S X E JefferisMRC LMB, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0002-0587-9355
Vincent CrosetDepartment of Biosciences, Durham University, Durham, United Kingdom.ORCID https://orcid.org/0000-0001-9696-766X
Alicia HidalgoBirmingham Centre for Neurogenetics, School of Biosciences, University of Birmingham, Birmingham, United Kingdom.ORCID https://orcid.org/0000-0001-8041-5764

Funding

Biotechnology and Biological Sciences Research Council BB/P004997/1Biotechnology and Biological Sciences Research Council BB/R00871X/1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior SWB PhD ScholarshipDarwin Trust of Edinburgh PhD StudentshipHORIZON EUROPE Marie Sklodowska-Curie Actions TOLKEDAWellcome Trust 223197Wellcome Trust 223197/Z/21/Z
6 · The paper itself

Abstract

Experience shapes the brain as neural circuits can be modified by neural stimulation or the lack of it. The molecular mechanisms underlying structural circuit plasticity and how plasticity modifies behaviour are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns a value to stimuli, and it also controls behaviour, including locomotion, learning, and memory. In

Indexed as

Dopaminergic NeuronsDrosophila ProteinsNeuronal PlasticityAnimalsDrosophilaDrosophila melanogasterLocomotionNerve Growth FactorsToll-Like ReceptorsDrosophila ProteinsNerve Growth FactorsToll-Like Receptorscell biologyD. melanogasterDNT-2kekneurodegenerationneurosciencestructural plasticitysynaptogenesisToll

Identifiers

PMID39704728
PMCPMC11661795

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.