Evidence map›Paper›PMID 39705976›Full record

ArticleEnvironment international2025

Associations of early life per- and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2-18 years: Mixture analysis in the prospective Boston Birth Cohort.

Zeyu Li, Guoying Wang, Joseph M Braun, Xiumei Hong, Giehae Choi, Shawn P O'Leary, Chang Ho Yu, Colleen Pearson, William G Adams, Zhihua Tina Fan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zeyu LiCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Guoying WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Joseph M BraunDepartment of Epidemiology, Brown University, Providence, RI, USA.
Xiumei HongCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Giehae ChoiDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Shawn P O'LearyEnvironmental and Chemical Laboratory Services, Public Health and Environmental Laboratories, New Jersey Department of Health, Trenton, NJ, USA.
Chang Ho YuEnvironmental and Chemical Laboratory Services, Public Health and Environmental Laboratories, New Jersey Department of Health, Trenton, NJ, USA.
Colleen PearsonDepartment of Pediatrics, Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, MA, USA.
William G AdamsDepartment of Pediatrics, Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, MA, USA.
Zhihua Tina FanEnvironmental and Chemical Laboratory Services, Public Health and Environmental Laboratories, New Jersey Department of Health, Trenton, NJ, USA.
Jessie P BuckleyDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: [email protected].
Xiaobin WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: [email protected].

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Preterm Birth, Maternal and Cord Blood Metabolome, and Child Metabolic RiskR01HD041702 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Frank B Hu, XIAOBIN WANG · 2001 to 2026
$11.1M
Immune Development Across the Life Course: Integrating Exposures and Multi-Omics in the Boston Birth CohortU01ES034983 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Hongkai Ji, Harry Benjamin Larman · 2022 to 2026
$3.9M
Endocrine disrupting chemical mixtures and bone health in adolescenceR01ES033252 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUCKLEY, JESSIE P · 2021 to 2025
$3.0M
Inter-generational Link of Cardio-Metabolic Risk: Integrate Multi-OMICs with Birth CohortR01HD098232 · NICHD · JOHNS HOPKINS UNIVERSITY · PI LIANG, LIMING, WANG, XIAOBIN · 2019 to 2022
$2.7M
Early Life Phthalate and Perfluoroalkyl Substance Exposures and Childhood Bone HealthR01ES030078 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUCKLEY, JESSIE P · 2019 to 2023
$2.1M
Functional RNA Modifications, Micronutrient Exposure, Developmental DisabilitiesR01ES031521 · NIEHS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WANG, XIAOBIN, XIE, HEHUANG · 2020 to 2024
$1.9M
Maternal Exposure to Low Level Mercury, Metabolome, and Child Cardiometabolic Risk in Multi-Ethnic Prospective Birth CohortsR01ES031272 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI WANG, GUOYING, WANG, XIAOBIN · 2020 to 2024
$1.2M
Maternal exposure to chemicals and offspring neurodevelopmental disabilities: informing public health actions by understanding nutritional modifiers and simulating interventionsR00ES035464 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI CHOI, GIEHAE · 2024 to 2025
$747k
Maternal exposure to chemicals and offspring neurodevelopmental disabilities: informing public health actions by understanding nutritional modifiers and simulating interventionsK99ES035464 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI CHOI, GIEHAE · 2023 to 2023
$98k
NCEH CDC HHS U88 EH001151NICHD NIH HHS R01 HD041702NICHD NIH HHS R01 HD098232NIEHS NIH HHS K99 ES035464NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R00 ES035464NIEHS NIH HHS R01 ES030078NIEHS NIH HHS R01 ES031272NIEHS NIH HHS R01 ES031521NIEHS NIH HHS R01 ES033252NIEHS NIH HHS U01 ES034983
6 · The paper itself

Abstract

backgroundPer- and polyfluoroalkyl substances (PFAS) are a class of widespread persistent chemicals, which may have obesogenic effects during the fetal period. This study investigated the long-term association of maternal plasma PFAS concentrations at delivery and their mixture with child body mass index (BMI) and the risk of Overweight or Obesity (OWO) at the age of 2-18 years.

methodsThe study included 1189 mother-child dyads from the prospective Boston Birth Cohort. Eight PFAS were measured in maternal plasma samples collected 24-72 h after delivery. Outcomes were BMI Z-score and OWO status of children at 2-18 years. The exposure-outcome associations were evaluated with linear and modified Poisson mixed-effects regression for individual PFAS and Bayesian kernel machine regression and quantile-based g-computation models for PFAS mixture. We explored the effect modification by maternal pre-pregnancy OWO, child age, sex, and race.

resultsMaternal plasma samples had PFAS detection frequencies from 87 % to 100 % and geometric means ranging from 0.11 to 3.67 ng/mL. PFHpS and PFHxS were associated with higher child BMI Z-score. Such associations were stronger in children aged 6-12 years and 13-18 years than in 2-5 years. Stratified by maternal pre-pregnancy OWO, significant associations of the PFAS mixture with child BMI Z-score were only found in children of non-OWO mothers. In children aged 13-18 years, children with both high maternal plasma PFDeA, PFNA, and PFOA concentrations and maternal OWO had the highest risks of OWO compared to children with either only. Such synergistic effects were not found in younger children.

conclusionsEarly life exposure to individual PFAS and their mixture were associated with a higher risk of childhood OWO, with stronger associations observed in older child age groups and in children of non-OWO mothers. Synergistic effects of PFAS exposures and maternal pre-pregnancy OWO became evident in adolescence.

Indexed as

Body Mass IndexEnvironmental ExposureEnvironmental PollutantsFluorocarbonsOverweightAdolescentAdultBirth CohortBostonChildChild, PreschoolEnvironmental PollutionFemaleHumansMaleMaternal ExposureEnvironmental PollutantsFluorocarbonsBMIChildhood overweight or obesityDOHaD theoryMaternal overweight or obesityPFASPrenatal exposure

Identifiers

PMID39705976
PMCPMC11786237

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.