Evidence map›Paper›PMID 39706227›Full record

ReviewArquivos de neuro-psiquiatria2024

Recent advances in autoimmune encephalitis.

João Henrique Fregadolli Ferreira, Caio César Diniz Disserol, Bruna de Freitas Dias, Alexandre Coelho Marques, Marina Driemeier Cardoso, Pedro Victor de Castro Silva, Fabio Fieni Toso, Lívia Almeida Dutra

Abstract readReview
In one paragraph

Review in Arquivos de neuro-psiquiatria, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Tele-assessment in limb-girdle muscular dystrophy: feasibility and reliability of patient-led asynchronous method.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

João Henrique Fregadolli FerreiraHospital Israelita Albert Einstein, Instituto do Cérebro, São Paulo SP, Brazil.ORCID 0000-0002-5226-8354
Caio César Diniz DisserolHospital Israelita Albert Einstein, Instituto do Cérebro, São Paulo SP, Brazil.ORCID 0000-0001-7568-0897
Bruna de Freitas DiasHospital Israelita Albert Einstein, Instituto do Cérebro, São Paulo SP, Brazil.ORCID 0000-0001-5336-0606
Alexandre Coelho MarquesHospital Israelita Albert Einstein, Instituto do Cérebro, São Paulo SP, Brazil.ORCID 0009-0007-0827-7281
Marina Driemeier CardosoHospital Israelita Albert Einstein, Instituto do Cérebro, São Paulo SP, Brazil.ORCID 0009-0001-4948-4195
Pedro Victor de Castro SilvaHospital Israelita Albert Einstein, Instituto do Cérebro, São Paulo SP, Brazil.ORCID 0000-0001-8686-6558
Fabio Fieni TosoHospital Israelita Albert Einstein, Instituto do Cérebro, São Paulo SP, Brazil.ORCID 0009-0008-4116-7858
Lívia Almeida DutraHospital Israelita Albert Einstein, Instituto do Cérebro, São Paulo SP, Brazil.ORCID 0000-0001-6309-9077

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the description of autoimmune encephalitis (AE) associated with N-methyl-D-aspartate receptor antibodies (anti-NMDARE) in 2007, more than 12 other clinical syndromes and antibodies have been reported. In this article, we review recent advances in pathophysiology, genetics, diagnosis pitfalls, and clinical phenotypes of AE associated with cell surface antibodies and anti-GAD associated neurological syndromes. Genetic studies reported human leukocyte antigen (HLA) associations for anti-LGI1, anti-Caspr2, anti-IgLON5, and anti-GAD. Follow-up studies characterized cognitive dysfunction, psychiatric symptoms, sleep disorders, and adaptative behavior dysfunction, mainly for anti-NMDARE. Late-onset anti-NMDARE and anti- GABA-B receptor (GABA-BR) encephalitis patients were described to have worse prognoses and different tumor associations. Additionally, the clinical spectrum of anti-LGI1, anti-AMPAR, anti-CASPR2, and anti-IgLON5 was expanded, comprising new differential diagnoses. The diagnostic criteria for AE were adapted to the pediatric population, and a diagnostic algorithm was proposed, considering potential mimics and misdiagnosis. We also review the limitations of commercial assays for AE and treatment recommendations, as well as clinical scales for short and long-term assessment of AE patients, along with cognitive evaluation.

Indexed as

AutoantibodiesEncephalitisDiagnosis, DifferentialHashimoto DiseaseHumansReceptors, N-Methyl-D-AspartateAutoantibodiesReceptors, N-Methyl-D-Aspartate

Identifiers

PMID39706227
PMCPMC11661894

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.