Evidence map›Paper›PMID 39706570›Full record

ReviewCells & development2025

The evolutionary origin and mechanism of chordate tail regeneration. An ancient tale?

Wouter Masselink, Prayag Murawala

Abstract readReview
In one paragraph

Review in Cells & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Wouter MasselinkInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), 1030 Vienna, Austria. Electronic address: wouter.masselink@imba.oeaw.ac.at.
Prayag MurawalaMDI Biological laboratory (MDIBL), Bar Harbor, ME 04609, USA; Department of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany. Electronic address: pmurawala@mdibl.org.

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI JAMES A COFFMAN · 2012 to 2026
$60.0M
Understanding the role of thyroid hormone signaling during axolotl limb regenerationP20GM104318 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI DRUMMOND, IAIN A. · 2013 to 2023
$23.0M
The MDIBL Center for Comparative Biology of Tissue Repair, Regeneration and AgingP30GM154610 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI IAIN A. DRUMMOND · 2024 to 2026
$5.0M
Development and validation of genetic cell ablation systems in axolotlR21OD031971 · OD · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI MURAWALA, PRAYAG · 2022 to 2023
$457k
NIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20 GM104318NIGMS NIH HHS P30 GM154610NIH HHS R21 OD031971
6 · The paper itself

Abstract

Chordate tail regeneration represents the remarkable ability of some chordates to partially or completely regenerate a significant portion of their primary body axis. In this review we will discuss the chordate regenerative ability, what is known about the cellular sources which contribute to the regenerating tail, how various structures such as the spinal cord and vertebral column are re-established, and how scaling of the regenerating tail is regulated. Finally, we propose that tail regeneration is evolutionarily conserved and is fundamentally different from tail development however the origin and mechanism of this process remain elusive.

Indexed as

Biological EvolutionChordataRegenerationTailAnimalsEvolutionLineagesPatterningRegenerationTail

Identifiers

PMID39706570
PMCPMC12174470

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.