Evidence map›Paper›PMID 39706583›Full record

ArticleJournal of the American Chemical Society2025

Enhancing Proton-Coupled Electron Transfer in Blue Light Using FAD Photoreceptor AppA

YongLe He, Agnieszka A Gil, Sergey P Laptenok, Anam Fatima, Jinnette Tolentino Collado, James N Iuliano, Helena A Woroniecka, Richard Brust, Aya Sabbah, Michael Towrie and 6 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Protein design accelerates the development and application of optogenetic tools.Computational and structural biotechnology journal · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

YongLe HeDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.
Agnieszka A GilDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.ORCID 0000-0001-7583-3080
Sergey P LaptenokSchool of Chemistry, University of East Anglia, Norwich NR4 7TJ, United Kingdom.ORCID 0000-0002-6468-3010
Anam FatimaSchool of Chemistry, University of East Anglia, Norwich NR4 7TJ, United Kingdom.ORCID 0000-0003-2388-4390
Jinnette Tolentino ColladoDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.
James N IulianoDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.ORCID 0000-0003-1213-3292
Helena A WoronieckaDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.
Richard BrustDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.ORCID 0000-0002-9200-1101
Aya SabbahDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.
Michael TowrieCentral Laser Facility, Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot OX11 0QX, United Kingdom.
Gregory M GreethamCentral Laser Facility, Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot OX11 0QX, United Kingdom.ORCID 0000-0002-1852-3403
Igor V SazanovichCentral Laser Facility, Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot OX11 0QX, United Kingdom.
Jarrod B FrenchDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.ORCID 0000-0002-6762-1309
Andras LukacsSchool of Chemistry, University of East Anglia, Norwich NR4 7TJ, United Kingdom.ORCID 0000-0001-8841-9823
Stephen R MeechSchool of Chemistry, University of East Anglia, Norwich NR4 7TJ, United Kingdom.ORCID 0000-0001-5561-2782
Peter J TongeDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.ORCID 0000-0003-1606-3471

Funding

IRACDA - The New York Consortium for the Advancement of Postdoctoral Scholars (NY CAPS)Phase IIK12GM102778 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Carol A. Carter, Karian Janice Wright · 2012 to 2026
$13.1M
SBU Chemistry-Biology Interface Training ProgramT32GM092714 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI SAMPSON, NICOLE S, TONGE, PETER J · 2010 to 2019
$1.7M
NIGMS NIH HHS K12 GM102778NIGMS NIH HHS T32 GM092714
6 · The paper itself

Abstract

The Blue Light Using FAD (BLUF) photoreceptor utilizes a noncovalently bound FAD to absorb light and trigger the initial ultrafast events in receptor activation. FAD undergoes 1 and 2 electron reduction as an enzyme redox cofactor, and studies on the BLUF photoreceptor PixD revealed the formation of flavin radicals (FAD

Indexed as

Flavin-Adenine DinucleotideLightProtonsBacterial ProteinsBlue LightElectron TransportHydrogen BondingModels, MolecularOxidation-ReductionPhotoreceptors, MicrobialRhodobacter sphaeroidesBacterial ProteinsFlavin-Adenine DinucleotidePhotoreceptors, MicrobialProtons

Identifiers

PMID39706583
PMCPMC11726546

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.