Evidence map›Paper›PMID 39706830›Full record

ArticleNPJ Regenerative medicine2024

Stroke-induced neuroplasticity in spiny mice in the absence of tissue regeneration.

Benjamin M Kidd, Justin A Varholick, Dana M Tuyn, Pradip K Kamat, Zachary D Simon, Lei Liu, Mackenzie P Mekler, Marjory Pompilus, Jodi L Bubenik, Mackenzie L Davenport and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Regenerative medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Benjamin M KiddDepartment of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL, USA.ORCID http://orcid.org/0009-0001-8074-8160
Justin A VarholickDepartment of Biology, College of Liberal Arts and Sciences and the Genetics Institute, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-2822-9045
Dana M TuynDepartment of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL, USA.
Pradip K KamatDepartments of Anesthesiology, Neurology, Psychology, and Pharmaceutics, Center for Translational Research in Neurodegenerative Disease, and the College of Medicine, University of Florida, Gainesville, FL, USA.
Zachary D SimonDepartment of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, USA.
Lei LiuDepartment of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, USA.
Mackenzie P MeklerDepartment of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL, USA.
Marjory PompilusDepartment of Psychiatry and the McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, USA.
Jodi L BubenikDepartment of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL, USA.
Mackenzie L DavenportDepartment of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL, USA.
Helmut A CarterDepartment of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL, USA.
Matteo M GrudnyDepartment of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0001-7133-9173
W Brad BarbazukDepartment of Biology, College of Liberal Arts and Sciences and the Genetics Institute, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-0909-4563
Sylvain DoréDepartment of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, USA.
Marcelo FeboDepartment of Psychiatry and the McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, USA.
Eduardo Candelario-JalilDepartment of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-3631-1989
Malcolm MadenDepartment of Biology, College of Liberal Arts and Sciences and the Genetics Institute, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0001-7178-5309
Maurice S SwansonDepartment of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL, USA. mswanson@ufl.edu.ORCID http://orcid.org/0000-0001-6245-5367

Funding

Upgrade of an 11T/40cm MRI/S SystemS10RR025671 · NCRR · UNIVERSITY OF FLORIDA · PI EDISON, ARTHUR S · 2009 to 2009
$500k
NCRR NIH HHS S10 RR025671U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS048843
6 · The paper itself

Abstract

Stroke is a major cause of disability for adults over 40 years of age. While research into animal models has prioritized treatments aimed at diminishing post-stroke damage, no studies have investigated the response to a severe stroke injury in a highly regenerative adult mammal. Here we investigate the effects of transient ischemia on adult spiny mice, Acomys cahirinus, due to their ability to regenerate multiple tissues without scarring. Transient middle cerebral artery occlusion was performed and Acomys showed rapid behavioral recovery post-stroke yet failed to regenerate impacted brain regions. An Acomys brain atlas in combination with functional (f)MRI demonstrated recovery coincides with neuroplasticity. The strength and quality of the global connectome are preserved post-injury with distinct contralateral and ipsilateral brain regions compensating for lost tissue. Thus, we propose Acomys recovers functionally from an ischemic stroke injury not by tissue regeneration but by altering its brain connectome.

Identifiers

PMID39706830
PMCPMC11662029

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.