Evidence map›Paper›PMID 39707033›Full record

ReviewDiscover oncology2024

Converging frontiers in cancer treatment: the role of nanomaterials, mesenchymal stem cells, and microbial agents-challenges and limitations.

Hamed Afkhami, Aref Yarahmadi, Shoroq Bostani, Nahid Yarian, Mahdieh Sadat Haddad, Shima Sadat Lesani, Seyed Soheil Aghaei, Mohammad Reza Zolfaghari

Abstract readReview
In one paragraph

Review in Discover oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hamed AfkhamiCellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.
Aref YarahmadiDepartment of Biology, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran.
Shoroq Bostani *Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran.
Nahid Yarian *Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran.
Mahdieh Sadat Haddad *Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran.
Shima Sadat Lesani *Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran.
Seyed Soheil AghaeiDepartment of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran. soheilaghaee@yahoo.com.
Mohammad Reza ZolfaghariDepartment of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran. mreza.zolfaghary@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Globally, people widely recognize cancer as one of the most lethal diseases due to its high mortality rates and lack of effective treatment options. Ongoing research into cancer therapies remains a critical area of inquiry, holding significant social relevance. Currently used treatment, such as chemotherapy, radiation, or surgery, often suffers from other problems like damaging side effects, inaccuracy, and the lack of ability to clear tumors. Conventional cancer therapies are usually imprecise and ineffective and usually develop resistance to treatments and cancer recurs. Cancer patients need fresh and innovative treatment that can reduce side effects while maximizing effectiveness. In recent decades several breakthroughs in these, and other areas of medical research, have paved the way for new avenues of fighting cancer including more focused and more effective alternatives. This study reviews exciting possibilities for mesenchymal stem cells (MSCs), nanomaterials, and microbial agents in the modern realm of cancer treatment. Nanoparticles (NPs) have demonstrated surprisingly high potential. They improve drug delivery systems (DDS) significantly, enhance imaging techniques remarkably, and target cancer cells selectively while protecting healthy tissues. MSCs play a double role in tissue repair and are a vehicle for novel cancer treatments such as gene treatments or NPs loaded with therapeutic agents. Additionally, therapies utilizing microbial agents, particularly those involving bacteria, offer an inventive approach to cancer treatment. This review investigates the potential of nanomaterials, MSCs, and microbial agents in addressing the shortcomings of conventional cancer therapies. We will also discuss the challenges and limitations of using these therapeutic approaches.

Indexed as

CancerCancer therapyMesenchymal stem cells (MSCs)Microbial agentsNanomaterials

Identifiers

PMID39707033
PMCPMC11662135

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.