Evidence map›Paper›PMID 39707135›Full record

ArticleCardiovascular engineering and technology2025

Design and Prototyping of a Novel Triple Lumen Photo-Angioplasty Device: Lumi-Solve-T.

Aldous Tria, Anak Dharma, Loren Spiegel, Andrew E Rodda, Asvini Allada, Pavel Sluka, Amarnath Sangeetha Menon, Ethan Prabaharan, Pulasthi V Wettesinghe, Justin W Adams and 2 more

Abstract read
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Article in Cardiovascular engineering and technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aldous TriaMonash Institute of Medical Engineering, Monash University, Melbourne, Australia.
Anak DharmaMonash Institute of Medical Engineering, Monash University, Melbourne, Australia.
Loren SpiegelMonash Institute of Medical Engineering, Monash University, Melbourne, Australia.
Andrew E RoddaMonash Institute of Medical Engineering, Monash University, Melbourne, Australia.
Asvini AlladaEastern Health Clinical School, Monash University, Melbourne, Australia.
Pavel SlukaEastern Health Clinical School, Monash University, Melbourne, Australia.
Amarnath Sangeetha MenonEastern Health Clinical School, Monash University, Melbourne, Australia.
Ethan PrabaharanEastern Health Clinical School, Monash University, Melbourne, Australia.
Pulasthi V WettesingheEastern Health Clinical School, Monash University, Melbourne, Australia.
Justin W AdamsDepartment of Anatomy and Developmental Biology, Monash University, Melbourne, Australia.
Manfred SpangerDepartment of Radiology, Eastern Health, Box Hill Hospital, Melbourne, Australia.
Anthony E DearEastern Health Clinical School, Monash University, Melbourne, Australia. Anthony.dear@monash.edu.ORCID 0000-0001-7832-2294

Funding

National Health and Medical Research Council 2013899
6 · The paper itself

Abstract

purposeA triple lumen iteration of the novel photo-angioplasty drug eluting balloon catheter (DEBc) Lumi-Solve may be compromised by guidewire shadow (GWS)-mediated attenuation of balloon surface drug activation. The current study aimed to design and evaluate a novel triple lumen prototype, designated Lumi-Solve-T, to circumvent these issues.

methodsEffects of guidewire shadowing (GWS) on vascular smooth muscle cell (VSMC) proliferation was evaluated using the MTT assay. In-silico modelling of GWS in the novel triple lumen design was conducted. Computer-aided design (CAD) and finite element analysis (FEA) contributed to development of a novel triple lumen catheter. 3D printing of rudimentary and refined prototypes of the catheter together with assembly of a novel fibre-optic (FO) complex and ex-vivo evaluation of the triple lumen device, Lumi-Solve T, was also performed.

resultsGW insertion in a parallel triple lumen FO: GW port orientation demonstrated significantly reduced inhibition of VSMC proliferation after 7 days confirming the need for an alternative triple lumen design. In-silico analysis identified a multi-fibre FO sleeve design supported uniform, radial and uninterrupted UV365nm light transmission to the angioplasty balloon surface. FEA confirmed a multi-fibre FO ribbon design afforded a practical method of FO sleeve generation and facilitated a novel hub configuration able to afford a FO ribbon to sleeve transition. 3D printed prototypes demonstrated the utility of the novel design.

conclusionsA dedicated third port and lumen for the Lumi-Solve FO is required for optimal balloon surface photo-activation. A novel triple lumen design, Lumi-Solve-T, incorporating a ribbon to sleeve FO transition and novel hub design offers a realistic solution to current device limitations.

Indexed as

Angioplasty, BalloonAngioplasty, Balloon, CoronaryCardiac CathetersComputer-Aided DesignMuscle, Smooth, VascularMyocytes, Smooth MuscleVascular Access DevicesAnimalsCell ProliferationCells, CulturedEquipment DesignFiber Optic TechnologyFinite Element AnalysisHumansPrinting, Three-Dimensional3D printingDrug eluting balloon angioplasty catheterFibre-opticGuide wire shadowPrototypingTriple lumen

Identifiers

PMID39707135

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.