Evidence map›Paper›PMID 39707178›Full record

Observational studyBMC cardiovascular disorders2024

The nadir platelet count in the first 48 h after ICU admission is a potential predictor of acute kidney injury in hemorrhagic shock patients.

Yufan Liang, Silin Liang, Jianyang Huang, Linhui Hu, Quanzhong Wu, Ziyun Li, Chixing Pan, Yuemei He, Xinjuan Zhou, Chunbo Chen

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yufan Liang *Department of Critical Care Medicine, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China.
Silin Liang *Department of Critical Care Medicine, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China.
Jianyang Huang *Emergency Department, The People's Hospital of Jiangmen, Jiangmen, China.
Linhui Hu *Department of Critical Care Medicine, Maoming People's Hospital, Maoming, China.
Quanzhong WuDepartment of Surgical Critical Care Medicine, Maoming People's Hospital, Maoming, China.
Ziyun LiGuangdong Medical University, Zhanjiang, China.
Chixing PanGuangdong Medical University, Zhanjiang, China.
Yuemei HeDepartment of Surgical Critical Care Medicine, Maoming People's Hospital, Maoming, China.
Xinjuan ZhouDepartment of Surgical Critical Care Medicine, Maoming People's Hospital, Maoming, China.
Chunbo ChenDepartment of Critical Care Medicine, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China. gghccm@163.com.

Funding

Major Program of Summit Project, Guangdong Province High-level Hospital Construction Project of Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences DFJH2020028National Natural Science Foundation of China 82172162Outstanding Young Medical Talents in Guangdong Province KJ012019445
6 · The paper itself

Abstract

backgroundThe relationship between the nadir platelet count within the first 48 h after intensive care unit (ICU) admission and the occurrence of acute kidney injury (AKI) in hemorrhagic shock patients remains unclear. This study investigated this association in adult patients admitted to the surgical ICU for hemorrhagic shock.

methodsWe included 124 hemorrhagic shock patients, excluding those with pre-existing AKI or chronic kidney disease (CKD), admitted to two affiliated hospitals between January 2019 and May 2022. The nadir platelet count was defined as the lowest value within the first 48 h after ICU admission. AKI was diagnosed based on Kidney Disease Improving Global Outcomes (KDIGO) criteria. We used multivariate logistic regression to identify independent risk factors for AKI and analyzed the area under the receiver operating characteristic curve (AUC) for diagnostic accuracy.

resultsPatients with AKI (n = 72) had significantly lower nadir platelet counts compared to those without AKI. The nadir platelet count was identified as an independent risk factor for AKI (OR = 0.988, 95% CI: 0.978-0.999, P = 0.035). The AUC for predicting AKI was 0.862 (95% CI: 0.795-0.929). Combining the nadir platelet count with serum cystatin C levels enhanced the predictive accuracy (AUC = 0.922, 95% CI: 0.870-0.973, P < 0.001).

conclusionsThe nadir platelet count in the first 48 h after ICU admission is independently associated with the risk of AKI in hemorrhagic shock patients and could serve as a potential predictor when combined with serum cystatin C levels.

Indexed as

Acute Kidney InjuryBiomarkersIntensive Care UnitsPatient AdmissionPredictive Value of TestsShock, HemorrhagicAdultAgedChinaCystatin CFemaleHumansMaleMiddle AgedPlatelet CountPrognosisBiomarkersCST3 protein, humanCystatin CAcute kidney injuryHemorrhagic shockNadir platelet countPredictor

Identifiers

PMID39707178
PMCPMC11660895

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.