Evidence map›Paper›PMID 39707372›Full record

ArticleLipids in health and disease2024

Association between simple, combined lipid markers and 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002-2022).

Ioanna Kechagia, Fotios Barkas, Evangelos Liberopoulos, Christina Chrysohoou, Petros P Sfikakis, Costas Tsioufis, Christos Pitsavos, Demosthenes Panagiotakos

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Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ioanna KechagiaDepartment of Nutrition and Dietetics, School of Health Sciences & Education, Harokopio University, Athens, 17676, Greece.
Fotios BarkasDepartment of Internal Medicine, Medical School, University of Ioannina, Ioannina, 45500, Greece.
Evangelos LiberopoulosFirst Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, 11527, Greece.
Christina ChrysohoouFirst Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, 11527, Greece.
Petros P SfikakisFirst Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, 11527, Greece.
Costas TsioufisFirst Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, 11527, Greece.
Christos PitsavosFirst Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, 11527, Greece.
Demosthenes PanagiotakosDepartment of Nutrition and Dietetics, School of Health Sciences & Education, Harokopio University, Athens, 17676, Greece. dbpanag@hua.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to evaluate the association between simple, combined lipid biomarkers, and 20-year cumulative incidence of new type 2 diabetes mellitus (T2DM) among adults participating in the ATTICA cohort study (2002-2022).

methodsThe present analysis included data from 2000 individuals free of T2DM at baseline (age 43 ± 13 years; 51% women). Sociodemographic, anthropometric, lifestyle, clinical, and biochemical parameters were collected at baseline and follow-up examinations; combined lipid markers were evaluated.

resultsThe 20-year cumulative incidence of T2DM was 26.3% (95%CI 24.4, 28.3%). All, simple and combined lipid markers were independently associated with new T2DM onset. The accuracy of simple and combined markers was approximately 75%, without any significant differences between simple and combined indices. The additive correct classification gain of lipid markers to glucose metabolism indices on 20-year new T2DM cumulative incidence varied between 0.9% for cardiometabolic index to 10.6% for LDL-cholesterol.

conclusionsLipid profile is associated with the long-term onset of T2DM. Evaluated through simple or combined markers, lipid profiles can be utilized for identifying and improving risk stratification in individuals at high risk for T2DM, while also enhancing the effectiveness of primary prevention measures and public health strategies.

Indexed as

BiomarkersDiabetes Mellitus, Type 2AdultCholesterol, LDLCohort StudiesFemaleHumansIncidenceLipidsMaleMiddle AgedRisk FactorsTriglyceridesBiomarkersCholesterol, LDLLipidsTriglyceridesIncidenceLipid markersMediterranean dietType 2 diabetes mellitus

Identifiers

PMID39707372
PMCPMC11660781

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.