ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025
An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies.
Abstract readConsensus Statement
In one paragraph
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
25 citing papers in PubMed.
- Semaglutide slows epigenetic aging in a randomized trial of HIV-associated lipohypertrophy.Nature communications · 2026Trial
- Relative impact of multidomain lifestyle interventions on deficit accumulation frailty over 24 months in the U.S. POINTER trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Trial
- Epigenetic Age Acceleration and Cardiometabolic Biomarkers in Response to Weight-Loss Dietary Interventions Among Obese Individuals: The MACRO Trial.Aging cell · 2025Trial
- Association of neurofilament light chain, CXCL9, IL-6, and TNFRSF11B with intrinsic capacity in community-dwelling older adults.GeroScience · 2026Article
- Supervised Exercise Intervention Restores Physical Activity and MultiOMIC-Derived Frailty Biomarkers in Older Adults.Journal of cachexia, sarcopenia and muscle · 2026Article
- Bioactive Compounds from Medicinal and Edible Plants for Anti-Aging: A Systematic Review of Molecular Mechanisms, Delivery Systems, and Clinical Evidence.Foods (Basel, Switzerland) · 2026Review
- Hierarchical endpoints and win statistics for geromedicine trials.Nature aging · 2026Review
- The Look AHEAD Research Program: A 25-Year Retrospective From the Perspective of Geroscience.Diabetes care · 2026Review
- Biomarkers of Inflammaging and Cellular Senescence in Musculoskeletal (MSK) Diseases: The Knowns and the Unknowns.Biomedicines · 2026Article
- Association between atrial fibrillation and systemic inflammation with muscle mass and strength trajectories in old age.GeroScience · 2026Article
- The Application of Metabolomics in Frailty: Trends, Challenges, and Future Directions.Metabolites · 2026Review
- Persistently raised inflammatory markers in a patient with resolved lower respiratory tract infection: a diagnostic challenge.Oxford medical case reports · 2026Article
- Biological age acceleration, longitudinal change and mortality risk in the Dutch Lifelines cohort.GeroScience · 2026Article
- Insights on geroscience pre-clinical and clinical trials to promote healthy aging from the Intrinsic Capacity, Frailty and Sarcopenia Research Task Force 2025.The Journal of frailty & aging · 2026Review
- Upskilling in Healthy Longevity Medicine and Its Association With Physicians' Implementation Intent and Self-Reported Clinical Confidence: Cross-Sectional Observational Study.JMIR medical education · 2026Observational
- Comparing fourteen consensus biomarkers of aging: epigenetic pace of aging as the strongest predictor of mortality in BASE-II.Biomarker research · 2026Article
- Age-related directional asymmetry in the rod-and-frame test.Frontiers in aging neuroscience · 2026Article
- Do we actually need aging clocks?npj aging · 2025Review
- Systemic Inflammation in Hip Fracture and Osteoarthritis: Insights into Pathways of Immunoporosis.International journal of molecular sciences · 2025Article
- White Paper on Nutrition Sensing and Ageing.Nutrition bulletin · 2025Article
Corrections and comments
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Authors and funding
64 authors.
Giorgia PerriHuman Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Chloe FrenchSchool of Health Sciences, University of Manchester, Manchester, UK.
César Agostinis-SobrinhoSport Physical Activity and Health Research & Innovation Center (SPRINT), Guarda, Portugal.
Atul AnandCentre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-6428-4554
Radiana Dhewayani AntariantoDepartment of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Yasumichi AraiCenter for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan.
Joseph A BaurDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-8262-6549
Omar CauliDepartment of Nursing, University of Valencia, Valencia, Spain.
Morgane Clivaz-DucCareConnex, Sierre, Valais, Switzerland.
Giuseppe CollocaDipartimento di Diagnostica per Immagini, Radioterapia Oncologica Ed Ematologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Constantinos DemetriadesMax Planck Institute for Biology of Ageing (MPI-AGE), Cologne, Germany.
Chiara de LuciaCentre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
Giorgio Di GessaDepartment of Epidemiology & Public Health, University College London, London, UK.ORCID 0000-0001-6154-1845
Breno S DinizUConn Center on Aging & Department of Psychiatry, University of Connecticut Medical School, Farmington, Connecticut, USA.ORCID 0000-0003-0653-1905
Catherine L DotchinPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Gillian EaglestoneInstitute for Lifecourse Development, School of Health Sciences, University of Greenwich, London, UK.
Bradley T ElliottAgeing Biology & Age Related Diseases, School of Life Sciences, University of Westminster, London, UK.
Mark A EspelandDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0002-3711-1949
Luigi FerrucciTranslational Gerontology Branch, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
James FisherSchool of Medicine, Newcastle University, Newcastle upon Tyne, UK.
Dimitris K GrammatopoulosBiomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
Novi S HardianyDepartment of Biochemistry & Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Zaki Hassan-SmithInstitute for Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Waylon J HastingsDepartment of Nutrition, Texas A&M University, College Station, Texas, USA.
Swati JainWorld Public Health Nutrition Association, Peacehaven, UK.
Peter K JoshiHumanity Inc, Humanity, Boston, Massachusetts, USA.
Theodora KatsilaInstitute of Chemical Biology, Laboratory of Biomarker Discovery & Translational Research, National Hellenic Research Foundation, Athens, Greece.
Graham J KempInstitute of Life Course and Medical Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.
Omid A KhaiyatSchool of Health and Sport Sciences, Musculoskeletal Health & Rehabilitation, Liverpool Hope University, Liverpool, UK.
Dudley W LammingDepartment of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-0079-4467
Jose Lara GallegosDepartment of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.
Frank MadeoInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Andrea B MaierHealthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-7206-1724
Carmen Martin-RuizBioScreening Core Facility, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Ian J MartinsSarich Neuroscience Research Institute, Edith Cowan University, Nedlands, Western Australia, Australia.
John C MathersHuman Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Lewis R MattinAgeing Biology & Age Related Diseases, School of Life Sciences, University of Westminster, London, UK.
Reshma A MerchantDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Alexey MoskalevInstitute of Biogerontology, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
Ognian NeytchevCollege of Medical, Veterinary & Life Sciences, School of Molecular Biosciences, University of Glasgow, Glasgow, UK.ORCID 0000-0002-9510-2135
Mary Ni LochlainnDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0001-5702-1759
Claire M OwenPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Stuart M PhillipsDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-1956-4098
Jedd PrattDepartment of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester, UK.ORCID 0000-0002-7410-078X
Konstantinos ProkopidisDepartment of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.ORCID 0000-0002-6264-9388
Nicholas J W RattrayStrathclyde Institute of Pharmacy and Biomedical Sciences, Faculty of Science, University of Strathclyde, Glasgow, UK.
María Rúa-AlonsoSport Physical Activity and Health Research & Innovation Center (SPRINT), Guarda, Portugal.
Lutz SchomburgInstitute for Experimental Endocrinology, Max Rubner Center, Charité University Berlin, Berlin, Germany.ORCID 0000-0001-9445-1555
David ScottInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.ORCID 0000-0001-5226-1972
Sangeetha ShyamInstitut d'Investigació Sanitària Pere Virgili (IISPV), Food, Nutrition, Development and Mental Health (ANUT-DSM) Research Group , Rovira i Virgili University, Reus, Spain.
Elina SillanpääGerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylän yliopisto, Finland.ORCID 0000-0001-6375-959X
Michelle M C TanPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-4806-7939
Ruth TehDepartment of General Practice and Primary Health Care, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand.ORCID 0000-0001-7135-1850
Stephanie W TobinTrent Centre for Aging & Society, Trent University, Peterborough, Ontario, Canada.
Carolina J Vila-ChãSport Physical Activity and Health Research & Innovation Center (SPRINT), Guarda, Portugal.
Luigi VorluniIndependent Researcher, Human Physiology and Integrative Medicine, London, UK.
Daniela WeberDepartment of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.ORCID 0000-0002-2054-6233
Ailsa WelchCentre for Population Health Research, Faculty of Health, University of East Anglia, Norwich, UK.
Daisy WilsonInstitute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID 0000-0001-7267-9487
Thomas WilsonDepartment of Life Sciences, Aberystwyth University, Ceredigion, UK.ORCID 0000-0003-3112-4682
Tongbiao ZhaoState Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Elena PhilippouDepartment of Life Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus.ORCID 0000-0003-0300-9572
Viktor I KorolchukFaculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Oliver M ShannonHuman Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Funding
Targeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and AgingR01DK098656 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Joseph A. Baur · 2013 to 2026
$6.1MAGEing and Nutrient SensingMedical Research CouncilNIDDK NIH HHS R01 DK098656UKRI's Biotechnology and Biological Sciences Research Council
Abstract
Biomarkers of aging serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of aging for use in intervention studies via the Delphi method. A 3-round Delphi study was conducted using an online platform. In Round 1, expert panel members provided suggestions for candidate biomarkers of aging. In Rounds 2 and 3, they voted on 500 initial statements (yes/no) relating to 20 biomarkers of aging. Panel members could abstain from voting on biomarkers outside their expertise. Consensus was reached when there was ≥70% agreement on a statement/biomarker. Of the 460 international panel members invited to participate, 116 completed Round 1, 87 completed Round 2, and 60 completed Round 3. Across the 3 rounds, 14 biomarkers met consensus that spanned physiological (eg, insulin-like growth factor 1, growth-differentiating factor-15), inflammatory (eg, high sensitivity C-reactive protein, interleukin-6), functional (eg, muscle mass, muscle strength, hand grip strength, Timed-Up-and-Go, gait speed, standing balance test, frailty index, cognitive health, blood pressure), and epigenetic (eg, DNA methylation/epigenetic clocks) domains. Expert consensus identified 14 potential biomarkers of aging which may be used as outcome measures in intervention studies. Future aging research should identify which combination of these biomarkers has the greatest utility.
Indexed as
AgingBiomarkersAgedDelphi TechniqueHumansBiomarkersConsensusDelphi methodLongevity
Identifiers
What Socratic holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.