ArticleHippocampus2025
Transcranial Direct Current Stimulation Over Bilateral Temporal Lobes Modulates Hippocampal-Occipital Functional Connectivity and Visual Short-Term Memory Precision.
Article in Hippocampus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Mental cost of simple(st) physical exertion.Cognition · 2026Article
- Medial temporal lobe lesions reduce visual working memory precision.Brain : a journal of neurology · 2026Article
- Hippocampal connectivity predicting recognition and categorization abilities.Frontiers in cognition · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Although the medial temporal lobe (MTL) is traditionally considered a region dedicated to long-term memory, recent neuroimaging and intracranial recording evidence suggests that the MTL also contributes to certain aspects of visual short-term memory (VSTM), such as the quality or precision of retained VSTM content. This study aims to further investigate the MTL's role in VSTM precision through the application of transcranial direct current stimulation (tDCS) and functional magnetic resonance imaging (fMRI). Participants underwent 1.5 mA offline tDCS over bilateral temporal lobes using left cathodal and right anodal electrodes, administered for either 20 min (active) or 0.5 min within a 20-min window (sham), in a counterbalanced design. As the electrical current passes through midbrain structures with this bilateral stimulation montage, prior behavioral and modeling evidence suggests that this tDCS protocol can modulate MTL functions. To confirm this and examine its impacts on VSTM, participants completed a VSTM color recall task immediately following tDCS, while undergoing a 20-min fMRI scan and a subsequent 7.5-min resting-state scan, during which they focused on a fixation cross. Behavioral results indicated that this tDCS protocol decreased VSTM precision without significantly affecting overall recall success. Furthermore, psychophysiological interaction analysis revealed that tDCS over the temporal lobe modulated hippocampal-occipital functional connectivity during the VSTM task, despite no main effect on fMRI BOLD activity. Notably, this modulation was also observed during resting-state fMRI 15-20 min post-tDCS, with the magnitude of the effect correlating with participants' behavioral changes in VSTM precision across active and control conditions. Combined, these findings suggest that tDCS over the temporal lobe can modulate the intrinsic functional connectivity between the MTL and visual sensory areas, thereby affecting VSTM precision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.