Evidence map›Paper›PMID 39711115›Full record

Observational studyEuropean journal of neurology2025

Hypoalbuminemia in status epilepticus is a biomarker of short- and long-term mortality: A 9-year cohort study.

Francesco Misirocchi, Hervé Quintard, Andrea O Rossetti, Irene Florindo, Oana E Sarbu, Andreas Kleinschmidt, Karl Schaller, Margitta Seeck, Pia De Stefano

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Role of albumin in regulating platelet function.Frontiers in pharmacology · 2026
    Article
  5. Observational
  6. Observational
  7. Status epilepticus: the score question.Frontiers in neurology · 2025
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francesco MisirocchiUnit of Neurology, Department of Medicine and Surgery, University of Parma, Parma, Italy.ORCID 0000-0001-8730-4397
Hervé QuintardDivision of Intensive Care, Department or Anesthesiology, Pharmacology, Intensive Care and Emergency Medicine, University Hospital of Geneva, Geneva, Switzerland.
Andrea O RossettiDepartment of Neurology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
Irene FlorindoUnit of Neurology, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Oana E SarbuDivision of Intensive Care, Department or Anesthesiology, Pharmacology, Intensive Care and Emergency Medicine, University Hospital of Geneva, Geneva, Switzerland.
Andreas KleinschmidtMedical Faculty of the University of Geneva, Geneva, Switzerland.
Karl SchallerMedical Faculty of the University of Geneva, Geneva, Switzerland.
Margitta SeeckMedical Faculty of the University of Geneva, Geneva, Switzerland.
Pia De StefanoDivision of Intensive Care, Department or Anesthesiology, Pharmacology, Intensive Care and Emergency Medicine, University Hospital of Geneva, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOutcome prediction in Status epilepticus (SE) aids in clinical decision-making, yet existing scores have limitations due to SE heterogeneity. Serum albumin is emerging as a readily available prognostic biomarker in various clinical conditions. This study evaluates hypoalbuminemia in predicting short- and long-term mortality.

methodsObservational cohort study including non-hypoxic SE adult patients admitted to the University Hospital of Geneva (Switzerland) between 2015 and 2023. Primary outcomes were in-hospital and 6-month mortality.

resultsFour hundred and ninety-six patients were included, 46 (9.3%) died in hospital; 6-month outcome was available for 364 patients, 86 (23.6%) were not alive at follow-up. Hypoalbuminemia was associated with older age and patients' comorbidities. Binomial regression showed an independent correlation between hypoalbuminemia and short- (p = 0.005, OR = 3.35, 95% CI = 1.43-7.86) and long-term mortality (p = 0.001, OR = 3.59,95% CI = 1.75-7.35). The Status Epilepticus Severity Score (STESS) had an overall AUC of 0.754 (95% CI = 0.656-0.836) for predicting in-hospital mortality and of 0.684 (95% CI = 0.613-0.755) for 6-month mortality. Through an exploratory analysis, we replaced age with hypoalbuminemia in the STESS, creating the Albumin-STESS (A-STESS) score (0-6). The global A-STESS AUC significantly improved for both in-hospital (0.837, 95% CI = 0.760-0.916, p = 0.002) and 6-month (0.739, 95% CI = 0.688-0.826; p = 0.033) mortality prediction. A-STESS-3 cutoff demonstrated a strong sensitivity-specificity balance for both in-hospital (sensitivity = 0.88, specificity = 0.68, accuracy = 0.70) and 6-month (sensitivity = 0.67, specificity = 0.73, accuracy = 0.72) mortality.

conclusionsHypoalbuminemia is an easily measurable biomarker reflecting the overall patient's condition and is independently related to short- and long-term SE mortality. Integrating hypoalbuminemia into the STESS (A-STESS) significantly enhances mortality prediction. Future studies are needed to externally validate the A-STESS and evaluate the benefits of albumin supplementation in SE patient prognosis.

Indexed as

BiomarkersHypoalbuminemiaStatus EpilepticusAdultAgedAged, 80 and overCohort StudiesFemaleHospital MortalityHumansMaleMiddle AgedPrognosisSeverity of Illness IndexBiomarkersalbuminICUoutcomestatus epilepticusSTESS

Identifiers

PMID39711115
PMCPMC11664120

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.