ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Life's Essential 8 and midlife trajectories in cognition and brain health: The CARDIA study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Accelerometer-Derived Relative Amplitude and Midlife Cognition: A Cross-Sectional Study.medRxiv : the preprint server for health sciences · 2026Article
- Menopause and neurological disorders: a roadmap for research.Nature reviews. Neurology · 2026Review
- Changes in DNA methylation-based aging predicts brain damage and dementia and reflects life-course cardiovascular risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of the cumulative modified life's Essential 8 score with cognitive change: Results from two longitudinal cohorts.The journal of prevention of Alzheimer's disease · 2026Article
- Life's Essential 8, genetic susceptibility, and risk of cognitive impairment: results from an elder population-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Retinal photographs to predict life's essential 8 for cardiovascular risk stratification: a novel deep-learning-based tool.European heart journal. Digital health · 2026Article
- Cumulative poverty across early adulthood and midlife cognition: findings from the national longitudinal survey of youth.Journal of epidemiology and community health · 2026Article
- Neighbourhood Socioeconomic Deprivation and Older Adults' Cognitive Decline in Porto, Portugal: A 13-Year (2005-2018) Longitudinal Analysis Using the Population-Based EPIPorto Cohort.International journal of public health · 2026Article
- Toward personalized medicine in AD/ADRD through genetic-exposome dementia risk assessments.NPJ dementia · 2026Review
- Novel associations between life's crucial 9 components and cognitive health in a National Cohort of Older Americans.Medicine · 2025Article
- Mitochondrial haplogroups, but not heteroplasmy, are associated with midlife cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Life's Essential 8 and midlife trajectories in cognition and brain health: The CARDIA study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- Adherence to Life's Essential 8 enhances gut microbiota diversity and cognitive performance.Frontiers in microbiomes · 2025Article
- Life's Essential 8 and cerebrovascular disease among Hispanic/Latino adults: findings from the Hispanic Community Health Study/Study of Latinos and Study of Latinos-Investigation of Neurocognitive Aging magnetic resonance imaging cohort.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
introductionPoor cardiovascular health (CVH) is linked to Alzheimer's disease and dementia; however, its association with neurocognitive trajectories earlier in life remains underexplored.
methodsWe included 3224 participants with information on CVH at early midlife (mean age 45.0 ± standard deviation 3.4) an cognitive assessments, and neuroimaging 5, 10, and 15 years later including white matter hyperintensities (WMHs), total gray matter (GM), and hippocampal volume. CVH was operationalized according to the American Heart Association's (AHA) "Life's Essential 8" (LE8) guidelines. The association between LE8 and cognitive and neuroimaging measures was examined using mixed linear regression adjusting for age, sex, race, and education.
resultsWorse LE8 score was associated with steeper decline in cognition, higher accumulation of WMHs, and steeper decline in total GM and hippocampal volume. DISCUSSION: Poor CVH is related to accelerated brain aging across midlife, highlighting the need to screen for and improve CVH earlier to prevent adverse cognitive outcomes. HIGHLIGHTS: Poor cardiovascular health in early midlife is associated with faster decline in cognition across 10 years overall and in specific domains. Poor and intermediate cardiovascular health was associated with higher accumulation of white matter hyperintensities across midlife. Poor cardiovascular health was associated with faster atrophy in total gray matter volume and hippocampal volume.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.